Table 2 Cox proportional Univariate analysis for Baseline Characteristics of Patients with or without Severe Hepatotoxicity
Characteristics of study the population | Level | Univariate Analysis | |||
|---|---|---|---|---|---|
No N (%) | Yes N (%) | OR(95%CI) | P | ||
Age group (Years) | <30 | 14 (51.9) | 1 3(48.1) | 1 | 0.02 |
30–40 | 33 (76.7) | 10 (23.3) | 0.15 (0.03–0.65) | ||
>40 | 25 (83.3) | 5 (16.7) | 0.40 (0.11–1.47) | ||
Gender | Male | 28 (59.6) | 19 (40.4) | 1 | 0.04 |
Female | 44 (83.0) | 9 (17.0) | 0.26 (0.89–5.28) | ||
Body Mass Index | Normal | 26 (83.9) | 5 (16.1) | 1 | 0.02 |
Low | 29 (61.7) | 18 (38.3) | 0.38 (0.04–3.35) | ||
Overweight | 6 (85.7) | 1 (14.3) | 0.30 (0.11–0.78) | ||
Obese | 11 (73.3) | 4 (26.7) | 0.20 (0.02–1.79) | ||
Level of Education | None | 4 (80.0) | 1 (20.0) | 1 | 0.89 |
Primary | 38 (74.5) | 13 (25.5) | 1.37 (0.14–13.38) | ||
Secondary | 26 (68.4) | 12 (31.6) | 1.84 (0.19–18.33) | ||
Tertiary | 4 (66.7) | 2 (33.3) | 2 (0.13–31.96) | ||
Monthly income | < 50,000 | 51 (66.2) | 26 (33.8) | 1 | 0.01 |
>50,000 | 21 (91.3) | 2 (8.7) | 0.18 (0.04–0.86) | ||
Alcohol intake | No | 33 ( 75) | 11 (25 ) | 1 | 0.07 |
Yes | 39 (69.6 ) | 17 (30.4) | 0.40 (0.11–1.47) | ||
Cigarette or tobacco intake | No | 56 (76.7) | 17 (23.3) | 1 | 0.09 |
Yes | 16 (59.3) | 11 (40.7) | 2.26 (0.88–5.80) | ||
Year of diagnosis | < 1 Year | 61 (72.6) | 23 (27.4) | 1 | 0.91 |
1–3 Years | 3 (75.0) | 1 (25.0) | 0.88 (0.09–8.94) | ||
>3 Years | 8 (66.7) | 4 (33.3) | 1.33 (0.36–4.83) | ||
CD4 Count values in cells/μl | <200 | 37 (64.9) | 20 (35.1) | 1 | 0.06 |
>200 | 35 (81.4) | 8 (18.6) | 0.42 (0.161.08) | ||
WHO stages | Stage 1 | 8 (57.1) | 6 (42.9) | 1 | 0.27 |
Stage2 | 32 (71.1) | 13 (28.9) | 0.54 (0.16–1.87) | ||
Stage 3 | 30 (81.1) | 7 (18.9) | 0.31 (0.08–1.19) | ||
Stage 4 | 2 (50.0) | 2 (50.0) | 1.33 (0.14–12.37) | ||
Name of ARV regimen | TDF+3TC+EFV | 46 (73.0) | 18 (27.0) | 1 | 0.01 |
AZT+3TC+ EFV | 20 (90.9) | 2 (9.1) | 0.25 (0.05–1.18) | ||
AZT+3TC+NVP | 6 (42.9) | 8 (57.1) | 2.86 (0.90–9.04) |