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Table 4 The cut-off points of FLI stratified by waist circumference and BMI based on the results of conventional ultrasonography in NHANES III

From: Population-specific cut-off points of fatty liver index: a study based on the National Health and Nutrition Examination Survey data

Stratification Total Fatty liver Prevalence (%) Cut-off points AUROC Sensitivity (true positive fraction) (%) Specificity (true negative fraction) (%) Positive likelihood ratio Negative likelihood ratio Youden index P value
Total 9214 3166 34.36 > 59.54 0.681 (0.671–0.691) 55.53 (53.8–57.3) 75.15 (74.0–76.2) 2.23 0.59 0.3068 < 0.0001
 Male 4290 1530 35.66 > 61.47 0.706 (0.692–0.720) 58.63 (56.1–61.1) 74.82 (73.2–76.4) 2.33 0.55 0.3345 < 0.0001
 Female 4924 1636 33.23 > 51.65 0.659 (0.645–0.672) 56.6 (54.2–59.0) 71.65 (70.1–73.2) 2.00 0.61 0.2826 < 0.0001
Stratified by BMI
BMI < 18.5a 190 55 28.95 ≤ 3.80 0.582 (0.508–0.653) 76.36 (63.0–86.8) 40.74 (32.4–49.5) 1.29 0.58 0.1710 0.0797
18.5 ≤ BMI < 25.0 3478 831 23.89 > 23.63 0.527 (0.511–0.544) 33.57 (30.4–36.9) 76.39 (74.7–78.0) 1.42 0.87 0.09962 0.0239
25.0 ≤ MI < 30.0 3191 1059 33.19 > 60.84 0.682 (0.666–0.698) 51.46 (48.4–54.5) 76.22 (74.4–78.0) 2.16 0.64 0.2768 < 0.0001
BMI ≥ 30.0 2355 1221 51.85 > 84.10 0.688 (0.669–0.707) 69.04 (66.4–71.6) 60.14 (57.2–63.0) 1.73 0.51 0.2918 < 0.0001
Male
 BMI < 18.5a 51 14 27.45 ≤ 3.74 0.670 (0.524–0.795) 71.43 (41.9–91.6) 64.86 (47.5–79.8) 2.03 0.44 0.3629 0.0625
 18.5 ≤ BMI < 25.0 1632 387 23.71 > 23.75 0.563 (0.538–0.587) 49.10 (44.0–54.2) 64.90 (62.2–67.6) 1.4 0.78 0.1400 0.0004
 25.0 ≤ BMI < 30.0 1741 609 34.98 > 60.47 0.683 (0.660–0.704) 61.58 (57.6–65.5) 6.70 (63.9–69.4) 1.85 0.58 0.2827 < 0.0001
 BMI ≥ 30.0 866 520 60.05 > 87.90 0.684 (0.652–0.715) 65.77 (61.5–69.8) 63.29 (58.0–68.4) 1.79 0.54 0.2906 < 0.0001
Female
 BMI < 18.5a 139 41 29.50 ≤ 1.23 0.559 (0.473–0.644) 21.95 (10.6–37.6) 95.92 (89.9–98.9) 5.38 0.81 0.1787 0.2880
 18.5 ≤ BMI < 25.0 1846 444 24.05 > 23.65 0.504 (0.481–0.527) 19.82 (16.2–23.8) 89.95 (85.1–88.7) 1.52 0.92 0.06767 0.8171
 25.0 ≤ BMI < 30.0 1450 450 31.03 > 45.44 0.679 (0.654–0.703) 60.67 (56.0–65.2) 70.40 (67.5–73.2) 2.05 0.56 0.3107 < 0.0001
 BMI ≥ 30.0 1489 701 47.08 > 82.60 0.680 (0.656–0.704) 67.05 (63.4–70.50 61.80 (58.3–65.2) 1.76 0.53 0.2885 < 0.0001
Stratified by BMI and WC
Male
WC < 102 3145 862 27.41 > 47.97 0.624 (0.607–0.641) 46.98 (43.6–50.4) 74.2 (72.4–76.0) 1.82 0.71 0.2118 < 0.0001
 BMI < 18.5a 51 14 27.45 ≤ 3.74 0.670 (0.524–0.795) 71.43 (41.9–91.6) 64.86 (47.5–79.8) 2.03 0.44 0.3629 0.0625
 18.5 ≤ BMI < 25.0 1620 382 23.58 > 23.75 0.560 (0.535–0.584) 48.43 (43.3–53.6) 65.27 (62.5–67.9) 1.39 0.79 0.1370 0.0008
 25.0 ≤ BMI < 30.0 1353 420 31.04 > 59.10 0.672 (0.647–0.697) 53.57 (48.7–58.4) 72.35 (69.4–75.2) 1.94 0.64 0.2592 < 0.0001
 BMI ≥ 30.0 121 46 38.02 > 79.25 0.688 (0.598–0.769) 50.00 (34.9–65.1) 80.00 (69.2–88.4) 2.5 0.63 0.3000 0.0002
WC ≥ 102 1145 668 58.34 > 87.73 0.665 (0.637–0.692) 56.59 (52.7–60.4) 70.23 (65.9–74.3) 1.90 0.62 0.2682 < 0.0001
 BMI < 18.5b 0           
 18.5 ≤ BMI < 25.0 12 5 41.67 > 54.66 0.657 (0.340–0.895) 40.00 (5.3–85.3) 100 (59.0–100.0) - 0.6 0.4 0.3989
 25.0 ≤ BMI < 30.0 388 189 48.71 > 67.07 0.623 (0.573–0.672) 74.60 (67.8–806) 45.23 (38.2–52.4) 1.36 0.56 0.1983 < 0.0001
 BMI ≥ 30.0 745 474 63.62 > 88.53 0.653 (0.618–0.687) 67.51 (63.1–71.7) 56.83 (50.7–62.8) 0.56 0.57 0.2434 < 0.0001
Female
WC < 88a 2323 552 23.76 ≤ 3.46 0.510 (0.489–0.530) 20.11 (16.8–23.7) 86.73 (85.1–88.3) 1.52 0.92 0.06839 0.5030
 BMI < 18.5a 138 41 29.71 ≤ 1.23 0.555 (0.468–0.640) 21.95 (10.6–37.6) 95.88 (89.8–98.9) 5.32 0.81 0.1783 0.3272
 18.5 ≤ BMI < 25.0a 1663 394 23.69 ≤ 3.46 0.510 (0.486–0.535) 20.56 (16.7–24.9) 86.68 (84.7–88.5) 1.54 0.92 0.07241 0.5536
 25.0 ≤ BMI < 30.0 489 110 22.49 > 41.89 0.562 (0.516–0.606) 28.18 (20.0–37.6) 89.18 (85.6–92.1) 2.61 0.81 0.1736 0.0697
 BMI ≥ 30.0 33 7 21.21 > 27.91 0.599 (0.414–0.765) 100.0 (59.0–100.0) 26.92 (11.6–47.8) 1.37 0.00 0.2692 0.4221
WC ≥ 88 2601 1084 41.68 > 70.28 0.685 (0.667–0.703) 62.18 (59.2–65.1) 65.66 (63.2–68.0) 1.81 0.58 0.2783 < 0.0001
 BMI < 18.5b 1 0          
 18.5 ≤ BMI < 25.0 183 50 27.32 > 35.26 0.552 (0.476–0.625) 44.0 (30.0–58.7) 67.67 (59.0–75.5) 1.36 0.83 0.1167 0.2748
 25.0 ≤ BMI < 30.0 961 340 35.38 > 51.64 0.694 (0.664–0.723) 64.12 (58.8–69.2) 66.18 (62.3–69.9) 1.9 0.54 0.3030 < 0.0001
 BMI ≥ 30.0 1456 694 47.66 > 82.60 0.676 (0.651–0.700) 67.72 (64.1–71.2) 60.50 (56.9–64.0) 1.71 0.53 0.2822 < 0.0001
  1. AUROC area under the receiver operating characteristic curves, BMI body mass index, WC waist circumference
  2. aThe calculated AUROC < 0.5, which cannot meet the requirements of diagnostic test
  3. bThe optimal cut-off point of FLI could not be obtained due to insufficient data