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Table 3 The cut-off points of FLI stratified by waist circumference and BMI based on the results of liver ultrasound transient elastograpy in NHANES 2017–2018

From: Population-specific cut-off points of fatty liver index: a study based on the National Health and Nutrition Examination Survey data

Stratification Total CAP > 248 Prevalence (%) Cut-off points AUROC Sensitivity (true positive fraction) (%) Specificity (true negative fraction) (%) Positive likelihood ratio Negative likelihood ratio Youden index P value
Total 4633 2721 58.73 > 45.60 0.833 (0.822–0.844) 80.85 (79.3–82.3) 70.50 (68.4–72.5) 2.74 0.27 0.5135 < 0.0001
Male 2281 1434 62.87 > 48.57 0.837 (0.821–0.852) 81.80 (79.7–83.8) 69.78 (66.6–72.9) 2.71 0.26 0.5157 < 0.0001
Female 2352 1287 54.72 > 41.93 0.829 (0.813–0.844) 80.34 (78.1–82.5) 70.89 (68.1–73.6) 2.76 0.28 0.5123 < 0.0001
Stratified by BMI
BMI < 18.5 76 7 9.21 > 5.10 0.588 (0.469–0.700) 71.43 (29.0–96.3) 68.12 (55.8–78.8) 2.24 0.42 0.3954 0.5294
18.5 ≥ BMI < 25.0 1191 308 25.86 > 20.77 0.760 (0.734–0.784) 63.31 (57.7–68.7) 78.71 (75.9–81.4) 2.97 0.47 0.4200 < 0.0001
25.0 ≥ BMI < 30.0 1477 863 58.43 > 44.73 0.732 (0.709–0.755) 72.54 (69.4–75.5) 61.56 (57.6–65.4) 1.89 0.45 0.3410 < 0.0001
BMI ≥ 30.0 1889 1543 81.68 > 86.00 0.743 (0.723–0.763) 68.05 (65.7–70.4) 67.92 (62.7–72.8) 2.12 0.47 0.3597 < 0.0001
Male
 BMI < 18.5a 31 4 12.90 ≤ 1.37 0.611 (0.420–0.780) 50.00 (6.8–93.2) 96.30 (81.0–99.9) 13.5 0.52 0.4630 0.6189
 18.5 ≥ BMI < 25.0 554 156 28.16 > 23.26 0.757 (0.719–0.792) 70.51 (62.7–77.5) 73.62 (69.0–77.9) 2.67 0.40 0.4413 < 0.0001
 25.0 ≥ BMI < 30.0 814 509 62.53 > 62.09 0.727 (0.695–0.757) 53.05 (48.6–57.5) 80.98 (76.1–85.2) 2.79 0.58 0.3403 < 0.0001
 BMI ≥ 30.0 882 765 86.73 > 91.35 0.725 (0.694–0.754) 55.95 (52.3–59.5) 78.63 (70.1–85.7) 2.62 0.56 0.3458 < 0.0001
Female
 BMI < 18.5 45 3 6.67 > 4.68 0.865 (0.730–0.948) 100 (2.92–100.0) 80.95 (65.9–91.4) 5.25 0.00 0.8095 < 0.0001
 18.5 ≥ BMI < 25.0 637 152 23.86 > 14.33 0.768 (0.733–0.800) 67.76 (59.7–75.1) 75.05 (71.0–78.8) 2.72 0.43 0.4281 < 0.0001
 25.0 ≥ BMI < 30.0 663 354 53.39 > 36.67 0.731 (0.695–0.764) 75.14 (70.3–79.6) 61.49 (55.8–66.9) 1.95 0.40 0.3663 < 0.0001
 BMI ≥ 30.0 1007 778 77.26 > 81.83 0.742 (0.714–0.769) 70.95 (67.6–74.1) 66.81 (60.3–72.9) 2.14 0.43 0.3776 < 0.0001
Stratified by BMI and WC
Male
WC < 102 1214 524 43.16 > 35.60 0.780 (0.755–0.803) 74.43 (70.5–78.1) 70.00 (66.4–73.4) 2.48 0.37 0.4443 < 0.0001
 BMI < 18.5a 31 4 12.90 ≤ 1.37 0.608 (0.426–0.771) 50.00 (6.8–93.2) 96.67 (82.8–99.9) 15.0 0.52 0.4667 0.6314
 18.5 ≥ BMI < 25.0 552 154 27.90 > 23.26 0.754 (0.716–0.789) 70.13 (62.2–77.2) 73.62 (69.0–77.9) 2.66 0.41 0.4375 < 0.0001
 25.0 ≥ BMI < 30.0 572 323 56.47 > 45.60 0.708 (0.669–0.745) 70.90 (65.6–75.8) 59.84 (53.5–66.0) 1.77 0.49 0.3074 < 0.0001
 BMI ≥ 30.0 59 43 72.88 > 68.03 0.686 (0.552–0.801) 67.44 (51.5–80.9) 68.75 (41.3–89.0) 2.16 0.47 0.3619 0.0223
WC ≥ 102 1067 910 85.29 > 85.04 0.718 (0.690–0.745) 66.37 (63.2–69.4) 66.24 (58.3–73.6) 1.97 0.51 0.3262 < 0.0001
 BMI < 18.5b 0           
 18.5 ≤ BMI < 25.0b 2 0          
 25.0 ≤ BMI < 30.0 242 186 76.86 > 63.30 0.679 (0.617–0.738) 69.89 (62.8–76.4) 60.71 (46.8–73.5) 1.78 0.5 0.3061 < 0.0001
 BMI ≥ 30.0 823 722 87.73 > 91.35 0.718 (0.686–0.749) 58.86 (55.2–62.5) 75.25 (65.7–83.3) 2.38 0.55 0.3411 < 0.0001
Female
WC < 88 721 157 21.78 > 14.29 0.774 (0.742–0.804) 67.52 (59.6–74.8) 77.48 (73.8–80.9) 3.00 0.42 0.4500 < 0.0001
 BMI < 18.5 45 3 6.67 > 4.68 0.865 (0.730–0.948) 100.00 (29.2–100) 80.95 (65.9–91.4) 5.25 0.00 0.8095 < 0.0001
 18.5 ≤ BMI < 25.0 526 99 18.82 > 11.58 0.751 (0.711–0.787) 65.66 (55.4–74.9) 74.71 (70.3–78.8) 2.6 0.46 0.4036 < 0.0001
 25.0 ≤ BMI < 30.0 146 54 36.99 > 23.48 0.736 (0.657–0.805) 68.52 (54.4–80.5) 70.65 (60.2–79.7) 2.33 0.45 0.3917 < 0.0001
 BMI ≥ 30.0b 4 1 25.00         
WC ≥ 88 1631 1130 69.28 > 75.28 0.748 (0.726–0.769) 58.23 (55.3–61.1) 78.64 (74.8–82.2) 2.73 0.53 0.3687 < 0.0001
 BMI < 18.5b 0           
 18.5 ≤ BMI < 25.0 111 53 47.75 > 30.65 0.629 (0.532–0.719) 58.49 (44.1–71.9) 68.97 (55.5–80.5) 1.88 0.6 0.2746 0.0171
 25.0 ≤ BMI < 30.0 517 300 58.03 > 36.67 0.706 (0.665–0.745) 82.33 (77.5–86.5) 49.77 (42.9–56.6) 1.64 0.35 0.3210 < 0.0001
 BMI ≥ 30.0 1003 777 77.47 > 81.83 0.740 (0.711–0.767) 71.04 (67.7–74.2) 66.37 (59.8–72.5) 2.11 0.44 0.3741 < 0.0001
  1. CAP controlled attenuation parameter, AUROC area under the receiver operating characteristic curves, BMI body mass index, WC waist circumference
  2. aThe calculated AUROC < 0.5, which can not meet the requirements of diagnostic test
  3. bThe optimal cut-off point of FLI could not be obtained due to insufficient data