Variables at diagnosis | Case of surgery, n | Person-days of follow-up, mean | Univariate | Multivariate | |||||
---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | ||||
Sex | |||||||||
Men | ref | 14 | 1217.974 | 1.00 | 1.00 | ||||
Women | 10 | 1124.727 | 2.56 | 1.14, 5.77 | 0.023* | 1.95 | 0.74, 5.13 | 0.176 | |
Age at diagnosis of CD | |||||||||
< 17 | 2 | 1014.3 | 1.00 | 0.23, 4.37 | 0.997 | 0.55 | 0.09, 3.31 | 0.509 | |
17–40 | ref | 16 | 1171.543 | 1.00 | 1.00 | ||||
40 < | 6 | 1397.722 | 1.29 | 0.50, 3.30 | 0.594 | 1.12 | 0.42, 2.98 | 0.816 | |
Smoking | |||||||||
Never | ref | 18 | 1160.5 | 1.00 | |||||
Current | 4 | 1209 | 0.95 | 0.32, 2.82 | 0.930 | ||||
Ex-smoker | 2 | 1394.25 | 0.55 | 0.13, 2.39 | 0.428 | ||||
Previous intestinal resection | |||||||||
No | ref | 19 | 1172.721 | 1.00 | 1.00 | ||||
Yes | 5 | 1237.135 | 0.41 | 0.15, 1.09 | 0.074 | 0.26 | 0.09, 0.76 | 0.014* | |
Perianal involvement | |||||||||
No | ref | 15 | 1336.688 | 1.00 | |||||
Yes | 9 | 934.1765 | 1.34 | 0.59, 3.08 | 0.484 | ||||
Disease location | |||||||||
L1 | ref | 14 | 1209.944 | 1.00 | |||||
L3 | 10 | 1181.205 | 0.93 | 0.41, 2.09 | 0.853 | ||||
CDAI score | |||||||||
< 150 | ref | 16 | 1289.013 | 1.00 | 1.00 | ||||
≥ 150 | 8 | 814.6316 | 2.91 | 1.23, 6.84 | 0.015* | 1.83 | 0.62, 5.41 | 0.273 | |
CRP | |||||||||
≤ 4 mg/L | ref | 17 | 1243.896 | 1.00 | |||||
> 4 mg/L | 7 | 1025.238 | 1.63 | 0.68, 3.94 | 0.275 | ||||
Endoscopic finding | |||||||||
Stricture length | |||||||||
< 2 cm | ref | 21 | 1239.076 | 1.00 | 1.00 | ||||
≥ 2 cm | 3 | 552.5 | 3.14 | 0.91, 10.81 | 0.069 | 3.31 | 0.68, 15.99 | 0.137 | |
Anastomotic site stricture | |||||||||
No | ref | 22 | 1189.899 | 1.00 | |||||
Yes | 2 | 1267.667 | 0.85 | 0.20, 3.64 | 0.831 | ||||
Location of stricture | |||||||||
TI | ref | 9 | 1250.667 | 1.00 | |||||
PI | 15 | 1138.563 | 0.52 | 0.22, 1.19 | 0.123 | ||||
J | 0 | 1701.333 | |||||||
Presence of ulcer at the stricture | |||||||||
No | ref | 4 | 1406.714 | 1.00 | 1.00 | ||||
Yes | 20 | 1080.556 | 3.19 | 1.08, 9.34 | 0.035* | 4.84 | 1.58, 14.79 | 0.006* | |
Concomitant treatment | |||||||||
Corticosteroid | |||||||||
No | ref | 22 | 1244.345 | 1.00 | |||||
Yes | 2 | 822.9091 | 0.90 | 0.21, 3.84 | 0.883 | ||||
5-aminosalicylate | |||||||||
No | ref | 11 | 1126.629 | 1.00 | |||||
Yes | 13 | 1236.159 | 0.64 | 0.29, 1.42 | 0.271 | ||||
Anti-TNF | |||||||||
No | ref | 15 | 1188.824 | 1.00 | |||||
Yes | 9 | 1205.957 | 0.62 | 0.27, 1.41 | 0.253 | ||||
Immunomodulator | |||||||||
No | ref | 15 | 1218.05 | 1.00 | |||||
Yes | 9 | 1163.868 | 1.04 | 0.46, 2.39 | 0.918 | ||||
Anti-TNF + Immunomodulator | |||||||||
No | ref | 20 | 1190.912 | 1.00 | |||||
Yes | 4 | 1224.278 | 0.91 | 0.31, 2.67 | 0.863 |