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Table 3 Predictive ustekinumab trough levels for laboratory and endoscopic remission

From: Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn’s disease

  CRP (≤ 0.3 mg/dL) Serum albumin (≥ 4.0 mg/dL) Endoscopic score (0 or 1)
n (yes/no) 23/5 16/12 8/20
AUC mean (95% CI) 0.86 (0.70–1.00) 0.78 (0.61–0.96) 0.80 (0.64–0.96)
P value 0.013 0.011 0.015
OR (95% CI) 7.9 (1.2–50.7) 3.2 (1.1–9.2) 2.6 (1.1–6.5)
Sensitivity 73.9 87.5 87.5
Specificity 80 66.7 65
UST trough cutoff (μg/mL) 1.71 1.71 2.04
  1. CRP, C-reactive protein; AUC, area under the curve; UST, ustekinumab; OR, odds ratio