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Table 3 Predictive ustekinumab trough levels for laboratory and endoscopic remission

From: Ustekinumab trough levels predicting laboratory and endoscopic remission in patients with Crohn’s disease

 

CRP (≤ 0.3 mg/dL)

Serum albumin (≥ 4.0 mg/dL)

Endoscopic score (0 or 1)

n (yes/no)

23/5

16/12

8/20

AUC mean (95% CI)

0.86 (0.70–1.00)

0.78 (0.61–0.96)

0.80 (0.64–0.96)

P value

0.013

0.011

0.015

OR (95% CI)

7.9 (1.2–50.7)

3.2 (1.1–9.2)

2.6 (1.1–6.5)

Sensitivity

73.9

87.5

87.5

Specificity

80

66.7

65

UST trough cutoff (μg/mL)

1.71

1.71

2.04

  1. CRP, C-reactive protein; AUC, area under the curve; UST, ustekinumab; OR, odds ratio