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Table 1 Sensitivity and specificity of CD10 and Das1 for individual complete and incomplete intestinal metaplastic glands

From: CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia

Biomarker

IM gland subtype

N0 of glands

N0 + ve glands

N0 − ve glands

Sensitivity

Specificity

PPV/

AUROC

(95% CI)a

(95% CI)a

NPV

CD10

        

All cohorts

        
 

Complete

123

112

11

91.1%

97.8%

98.2%/

0.944

 

Incomplete

92

2

90

(84.6–95.5%)

(92.4–99.7%)

89.1%

 

IM-GC

        
 

Complete

64

56

8

87.5%

100.0%

100.0%/

0.938

     

(76.9–94.5%)

(89.1–100.0%)

80.0%

 
 

Incomplete

32

0

32

    

IM + GC

        
 

Complete

59

56

3

94.9%

96.7%

96.6%/

0.958

 

Incomplete

60

2

58

(85.9–98.9%)

(88.5–99.6%)

95.1%

 

Das1

        

All cohorts

        
 

Complete

127

11

116

29.2%

91.3%

71.8%/

0.603

     

(20.3–39.3%)

(85.0–95.6%)

63.0%

 
 

Incomplete

96

28

68

    

IM-GC

        
 

Complete

60

1

59

28.6%

98.3%

85.7%/

0.635

 

Incomplete

21

6

15

(11.3–52.2%)

(91.1–100.0%)

79.7%

 

IM + GC

        
 

Complete

67

10

57

29.3%

85.1%

68.8%/

0.572

 

Incomplete

75

22

53

(19.4–40.1%)

(74.3–92.6%)

51.8%

 
  1. aConfidence intervals for sensitivity and specificity are Clopper–Pearson confidence intervals; PPV, Positive Predictive Value; NPV, Negative Predictive Value; AUROC, Area Under Receiver Operating Characteristic (ROCR package in R)
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BMC Gastroenterology

ISSN: 1471-230X

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