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Table 1 Ontologies significantly different for different tissue types

From: Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns

Ontology function/activity place p value Colon up Intestine up Stomach up Ontology function/activity place p value Colon up Intestine up Stomach up
Cellular response to cytokine stimulus 0.011 0.00% 9.09% 0.00% Negative regulation of protein localization to nucleus 0.032 0.85% 9.09% 0.00%
    Socs1     Trim40 Trim40  
Cellular response to organic cyclic compound 0.032 0.85% 9.09% 0.00% Negative regulation of signal transduction 0.02 0.85% 13.64% 2.56%
   Btrc Socs1     Socs5 Socs1
Socs3
Cish
Socs5
Cytokine-mediated signaling pathway 0.02 0.85% 13.64% 2.56% Negative regulation of tyrosine phosphorylation of STAT protein 0.001 0.00% 13.64% 0.00%
   Socs5 Socs1
Socs3
Cish
Socs5     Socs1
Socs3
 
Cytoplasmic ribonucleoprotein granule 0.011 0.00% 9.09% 0.00% Positive regulation of I-kappaB kinase/NF-kappaB signaling 0.042 1.69% 13.64% 2.56%
    Socs1     Mul1
Trim62
Mul1
Rnf31
Trim30
Trim13
Trim62
IkappaB kinase complex 0.032 0.85% 9.09% 0.00% Positive regulation of regulatory T cell differentiation 0.011 0.00% 9.09% 0.00%
   Trim40 Trim40      Socs1  
Insulin-like growth factor receptor binding 0.011 0.00% 9.09% 0.00% Protein kinase inhibitor activity 0.02 0.85% 13.64% 2.56%
    Socs1     Socs5 Socs1
Socs3
Socs5
Cish
Intracellular signal transduction 0.049 3.39% 18.18% 5.13% Protein neddylation 0.032 0.85% 9.09% 0.00%
   Socs5
Spsb4
Wsb1
Socs1
Socs3
Wsb1
Asb2
Cish
Socs5
   Trim40 Trim40  
JAK-STAT cascade 0.042 1.69% 13.64% 2.56% Regulation of activation of Janus kinase activity 0.011 0.00% 9.09% 0.00%
   Pias1
Socs5
Socs1
Socs3
Pias1
Socs5
    Socs1  
Negative regulation of insulin receptor signaling pathway 0.002 0.00% 13.64% 1.28% Regulation of cytokine secretion 0.011 0.00% 9.09% 0.00%
    Socs1
Socs3
Cish     Socs1  
Negative regulation of JAK-STAT cascade 0.02 0.85% 13.64% 2.56% Regulation of interferon-gamma-mediated signaling pathway 0.011 0.00% 9.09% 0.00%
   Socs5 Socs1
Socs3
Cish
Socs5
    Socs1  
Negative regulation of NF-kappaB transcription factor activity 0.032 0.85% 9.09% 0.00% Regulation of JAK-STAT cascade 0.011 0.00% 9.09% 0.00%
   Trim40 Trim40      Socs1  
Negative regulation of protein catabolic process 0.032 0.85% 9.09% 0.00% Regulation of protein phosphorylation 0.001 0.00% 13.64% 0.00%
   Trim40 Trim40      Socs1
Socs3
 
Negative regulation of protein kinase activity 0.02 0.85% 13.64% 2.56% Regulation of tyrosine phosphorylation of STAT protein 0.011 0.00% 9.09% 0.00%
   Socs5 Socs1
Socs3
Socs5
Cish
    Socs1