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Fig. 3 | BMC Gastroenterology

Fig. 3

From: Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns

Fig. 3

Spatial changes in expression of Ub-ligases of the same ontology group inside colonic crypts after induced epithelial damage. a Schematic illustration of the cell type residence in colonic crypt during homeostasis (based on (22, 38, 39, 41)). bd Epithelial damage causes a shift in the expression pattern of ubiquitin ligases and ubiquitination-related genes in distal colon along the crypt axis. e In situ hybridization images of the DSS treated and untreated colon demonstrate spatial changes in expression of genes obtained from the ontology combination GO:0045309 and GO:0044267, GO:0045309 and PW:0000417. Red arrow depicts the gene Cbl expression upregulated after the DSS-induced damage and blue arrows display the other specific genes downregulated after the damage. Scale = 50 µm

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