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Table 4 Sensitivity and specificity of the stool DNA test targeting methylated SDC2

From: A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA

  SDC2-Combine A&B SDC2-A SDC2-B P value
Sensitivity (95% CI) Sensitivity (95% CI) Sensitivity (95% CI)
CRC 87.25% (79.27–92.53%) 85.29% (77.03–91.00%) 83.33% (74.82–89.42%) 0.732
Advanced adenomas 52.00% (38.51–65.20%) 48.00% (34.80–61.49%) 52.00% (38.51–65.20%) 0.899
  SDC2-Combine A&B SDC2-A SDC2-B  
Specificity (95% CI) Specificity (95% CI) Specificity (95% CI)
Normal control 94.62% (89.11–97.56%) 96.15% (91.08–98.58%) 97.69% (93.14–99.51%) 0.435
Colitis 94.44% (72.35–99.99%) 94.44% (72.35–99.99%) 100.00% (79.33–100%) 0.595
Non‐advanced adenoma 89.74% (75.85–96.51%) 92.31% (78.97–98.06%) 94.87% (82.21–99.48%) 0.697