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Table 4 Comparison between nuclear parameters and clinical-pathological characteristics

From: Nuclear morphometry and chromatin texture changes in hepatocellular carcinoma samples may predict outcomes of liver transplanted patients

Characteristic

Area(µm2)

mean ± SD

p*

Perimeter(µm)

mean ± SD

p*

Circularity

mean ± SD

p*

Feret(µm)

mean ± SD

p*

ncMGV(µm)

mean ± SD

p*

Solidity

mean ± SD

p*

AR

mean ± SD

p*

FD

mean ± SD

p*

Sex

                

 Male

49.84 ± 15.30

0.606

26.92 ± 4.02

0.175

0.834 ± 0.04

0.868

87.36 ± 13.70

0.375

22.27 ± 9.97

0.812

0.981 ± 0.009

0.796

1.26 ± 0.09

0.212

1.17 ± 0.03

0.251

 Female

47.13 ± 1477

 

25.00 ± 3.98

 

0.823 ± 0.04

 

82.76 ± 16.16

 

23.10 ± 9.97

 

0.182 ± 0.009

 

1.31 ± 0,07

 

1.15 ± 0.03

 

Age (years)

                

 < 60

44.68 ± 15.63

0.123

25.68 ± 4.62

0.580

0.837 ± 0.04

0.280

80.01 ± 14.46

0.034

20.11 ± 10.4

0.136

0.980 ± 0.007

0.326

1.27 ± 0.09

0.879

1.17 ± 0.03

0.379

 = or > 60

52.61 ± 13.44

 

26.47 ± 3.50

 

0.821 ± 0.04

 

90.65 ± 13.47

 

25.16 ± 8,7

 

0.983 ± 0.010

 

1.28 ± 0.08

 

1.16 ± 0.03

 

Number tumor

                

 < or = 3

48.19 ± 14.94

0.486

26.01 ± 4.09

0.723

0.837 ± 0.04

0.059

85.12 ± 15.04

0.750

23.01 ± 9.85

0.390

0.982 ± 0.009

0.694

1.28 ± 0.08

0.614

1.16 ± 0.03

0.302

 > 3

55.91 ± 17.21

 

27.09 ± 4.58

 

0.769 ± 0.06

 

88.64 ± 13.13

 

16.74 ± 10.34

 

0.979 ± 0.007

 

1.25 ± 0.12

 

1.14 ± 0.05

 

Nodule size (cm)

                

 < or = 3

48.97 ± 11.68

0.884

25.55 ± 3.02

0.385

0.828 ± 0.04

0.859

84.46 ± 14.35

0.628

26.70 ± 1.13

0.784

0.983 ± 0.009

0.379

1.27 ± 0.08

0.507

1.15 ± 0.03

0.128

 > 3

47.97 ± 20.79

 

27.19 ± 5.68

 

0.834 ± 0.02

 

87.14 ± 16.21

 

23.32 ± 9.59

 

0.980 ± 0.009

 

1.34 ± 0.10

 

1.18 ± 0.03

 

Nuclear grade

                

 1

58.36 ± 14.18

0.757

27.52 ± 3.45

0.842

0.848 ± 0,02

0.796

94.57 ± 11.27

0.733

30.50 ± 18.15

0.064

0.996 ± 0.001

0.088

1.17 ± 0.01

0.145

1.13 ± 0.03

0.435

 2

51.33 ± 13.32

 

26.25 ± 3.32

 

0.821 ± 0.04

 

87.25 ± 14.48

 

23.89 ± 10.48

 

0.980 ± 0.008

 

1.29 ± 0.08

 

1.16 ± 0.06

 

 3

50.38 ± 14.44

 

25.90 ± 3.96

 

0.843 ± 0.05

 

85.07 ± 17.57

 

19.33 ± 6.30

 

0.981 ± 0.011

 

1.30 ± 0.09

 

1.15 ± 0.03

 

MELD

                

 < 20

50.99 ± 15.92

0.200

27.02 ± 4.06

0.066

0.828 ± 0.04

0.636

89.50 ± 14.89

0.024

23.84 ± 9.61

0.034

0.982 ± 0.009

0.975

1.28 ± 0.09

0.499

1.16 ± 0.03

0.279

 > 20

41.42 ± 4.44

 

23.44 ± 1.21

 

0.834 ± 0.04

 

73.17 ± 4.69

 

13.58 ± 7.13

 

0.982 ± 0.002

 

1.31 ± 0.08

 

1.14 ± 0.04

 

Recurrent

                

 Absent

48.53 ± 15.29

0.908

26.14 ± 4.19

0.802

0.823 ± 0.04

0.957

85.39 ± 15.40

0.951

21.92 ± 9.68

0.248

0.982 ± 0.009

0.921

1.29 ± 0.08

0.048

1.16 ± 0.03

0.946

 Present

49.48 ± 13.50

 

25.59 ± 3.36

 

0.971 ± 0.02

 

84.89 ± 10.48

 

28.04 ± 10.59

 

0.982 ± 0.009

 

1.21 ± 0.08

 

1.16 ± 0.03

 

Vascular inv

                

 Absent

48.23 ± 11.07

0.862

25.34 ± 2.81

0.256

0.827 ± 0.04

0.469

84.18 ± 13.80

0.574

23.10 ± 9.74

0.736

0.984 ± 0.009

0.123

1.29 ± 0.09

0.334

1.16 ± 0.03

0.504

 Present

49.31 ± 20.14

 

27.26 ± 5.44

 

0.834 ± 0.03

 

87.18 ± 16.66

 

21.90 ± 10.32

 

0.978 ± 0.009

 

1.26 ± 0.07

 

1.16 ± 0.03

 

Death

                

 No

46.91 ± 16.23

0.657

26.10 ± 4,48

0.829

0.830 ± 0.03

0.339

86.02 ± 16.28

0.836

21.62 ± 9.52

0.475

0.983 ± 0.008

0.658

1.30 ± 0.08

0.290

1.16 ± 0.03

0.892

 Yes

50.21 ± 12.48

 

25.87 ± 3.39

 

0.828 ± 0.05

 

84.60 ± 11.43

 

24.30 ± 11.67

 

0.981 ± 0.011

 

1.25 ± 0.09

 

1.16 ± 0.03

 

Survival (years)

                

 < 5

55.32 ± 14.10

0.014

27.08 ± 3.61

0.273

0.821 ± 0.04

0.132

92.84 ± 14.40

0.035

22.09 ± 9.02

0.076

0.984 ± 0.008

0.412

1.29 ± 0.09

0.440

1.16 ± 0.04

0.923

 > 5

39.52 ± 10.50

 

24.71 ± 4.26

 

0.843 ± 0.03

 

76.52 ± 8.12

 

23.35 ± 11.99

 

0.980 ± 0.009

 

1.27 ± 0.07

 

1.16 ± 0.03

 
  1. *p, statistical significance; SD standard deviation, µm micrometer, cm centimeter, ncMGV normalized corrected mean grey value, AR, aspect ratio, FD fractal dimension, MELD Model End-Stage Liver Disease, Vascular inv. Vascular invasion