Skip to main content

Table 4 Comparison between nuclear parameters and clinical-pathological characteristics

From: Nuclear morphometry and chromatin texture changes in hepatocellular carcinoma samples may predict outcomes of liver transplanted patients

Characteristic Area(µm2)
mean ± SD
p* Perimeter(µm)
mean ± SD
p* Circularity
mean ± SD
p* Feret(µm)
mean ± SD
p* ncMGV(µm)
mean ± SD
p* Solidity
mean ± SD
p* AR
mean ± SD
p* FD
mean ± SD
p*
Sex                 
 Male 49.84 ± 15.30 0.606 26.92 ± 4.02 0.175 0.834 ± 0.04 0.868 87.36 ± 13.70 0.375 22.27 ± 9.97 0.812 0.981 ± 0.009 0.796 1.26 ± 0.09 0.212 1.17 ± 0.03 0.251
 Female 47.13 ± 1477   25.00 ± 3.98   0.823 ± 0.04   82.76 ± 16.16   23.10 ± 9.97   0.182 ± 0.009   1.31 ± 0,07   1.15 ± 0.03  
Age (years)                 
 < 60 44.68 ± 15.63 0.123 25.68 ± 4.62 0.580 0.837 ± 0.04 0.280 80.01 ± 14.46 0.034 20.11 ± 10.4 0.136 0.980 ± 0.007 0.326 1.27 ± 0.09 0.879 1.17 ± 0.03 0.379
 = or > 60 52.61 ± 13.44   26.47 ± 3.50   0.821 ± 0.04   90.65 ± 13.47   25.16 ± 8,7   0.983 ± 0.010   1.28 ± 0.08   1.16 ± 0.03  
Number tumor                 
 < or = 3 48.19 ± 14.94 0.486 26.01 ± 4.09 0.723 0.837 ± 0.04 0.059 85.12 ± 15.04 0.750 23.01 ± 9.85 0.390 0.982 ± 0.009 0.694 1.28 ± 0.08 0.614 1.16 ± 0.03 0.302
 > 3 55.91 ± 17.21   27.09 ± 4.58   0.769 ± 0.06   88.64 ± 13.13   16.74 ± 10.34   0.979 ± 0.007   1.25 ± 0.12   1.14 ± 0.05  
Nodule size (cm)                 
 < or = 3 48.97 ± 11.68 0.884 25.55 ± 3.02 0.385 0.828 ± 0.04 0.859 84.46 ± 14.35 0.628 26.70 ± 1.13 0.784 0.983 ± 0.009 0.379 1.27 ± 0.08 0.507 1.15 ± 0.03 0.128
 > 3 47.97 ± 20.79   27.19 ± 5.68   0.834 ± 0.02   87.14 ± 16.21   23.32 ± 9.59   0.980 ± 0.009   1.34 ± 0.10   1.18 ± 0.03  
Nuclear grade                 
 1 58.36 ± 14.18 0.757 27.52 ± 3.45 0.842 0.848 ± 0,02 0.796 94.57 ± 11.27 0.733 30.50 ± 18.15 0.064 0.996 ± 0.001 0.088 1.17 ± 0.01 0.145 1.13 ± 0.03 0.435
 2 51.33 ± 13.32   26.25 ± 3.32   0.821 ± 0.04   87.25 ± 14.48   23.89 ± 10.48   0.980 ± 0.008   1.29 ± 0.08   1.16 ± 0.06  
 3 50.38 ± 14.44   25.90 ± 3.96   0.843 ± 0.05   85.07 ± 17.57   19.33 ± 6.30   0.981 ± 0.011   1.30 ± 0.09   1.15 ± 0.03  
MELD                 
 < 20 50.99 ± 15.92 0.200 27.02 ± 4.06 0.066 0.828 ± 0.04 0.636 89.50 ± 14.89 0.024 23.84 ± 9.61 0.034 0.982 ± 0.009 0.975 1.28 ± 0.09 0.499 1.16 ± 0.03 0.279
 > 20 41.42 ± 4.44   23.44 ± 1.21   0.834 ± 0.04   73.17 ± 4.69   13.58 ± 7.13   0.982 ± 0.002   1.31 ± 0.08   1.14 ± 0.04  
Recurrent                 
 Absent 48.53 ± 15.29 0.908 26.14 ± 4.19 0.802 0.823 ± 0.04 0.957 85.39 ± 15.40 0.951 21.92 ± 9.68 0.248 0.982 ± 0.009 0.921 1.29 ± 0.08 0.048 1.16 ± 0.03 0.946
 Present 49.48 ± 13.50   25.59 ± 3.36   0.971 ± 0.02   84.89 ± 10.48   28.04 ± 10.59   0.982 ± 0.009   1.21 ± 0.08   1.16 ± 0.03  
Vascular inv                 
 Absent 48.23 ± 11.07 0.862 25.34 ± 2.81 0.256 0.827 ± 0.04 0.469 84.18 ± 13.80 0.574 23.10 ± 9.74 0.736 0.984 ± 0.009 0.123 1.29 ± 0.09 0.334 1.16 ± 0.03 0.504
 Present 49.31 ± 20.14   27.26 ± 5.44   0.834 ± 0.03   87.18 ± 16.66   21.90 ± 10.32   0.978 ± 0.009   1.26 ± 0.07   1.16 ± 0.03  
Death                 
 No 46.91 ± 16.23 0.657 26.10 ± 4,48 0.829 0.830 ± 0.03 0.339 86.02 ± 16.28 0.836 21.62 ± 9.52 0.475 0.983 ± 0.008 0.658 1.30 ± 0.08 0.290 1.16 ± 0.03 0.892
 Yes 50.21 ± 12.48   25.87 ± 3.39   0.828 ± 0.05   84.60 ± 11.43   24.30 ± 11.67   0.981 ± 0.011   1.25 ± 0.09   1.16 ± 0.03  
Survival (years)                 
 < 5 55.32 ± 14.10 0.014 27.08 ± 3.61 0.273 0.821 ± 0.04 0.132 92.84 ± 14.40 0.035 22.09 ± 9.02 0.076 0.984 ± 0.008 0.412 1.29 ± 0.09 0.440 1.16 ± 0.04 0.923
 > 5 39.52 ± 10.50   24.71 ± 4.26   0.843 ± 0.03   76.52 ± 8.12   23.35 ± 11.99   0.980 ± 0.009   1.27 ± 0.07   1.16 ± 0.03  
  1. *p, statistical significance; SD standard deviation, µm micrometer, cm centimeter, ncMGV normalized corrected mean grey value, AR, aspect ratio, FD fractal dimension, MELD Model End-Stage Liver Disease, Vascular inv. Vascular invasion