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Table 2 Predictive factors for cervical LN metastasis (144 cases)

From: Development and validation of a nomogram for prediction of cervical lymph node metastasis in middle and lower thoracic esophageal squamous cell carcinoma

Predictors Univariate analysis Multivariable analysis
P OR (95% CI) P OR (95% CI)
Gender 1.00   
 Male   Reference  
 Female   1.00 (0.44–2.27)  
Age, years 0.47 0.99 (0.94–1.05)
Tumor location 0.17   
 Middle   Reference  
 Lower   0.46 (0.16–1.30)  
Degree of differentiation 0.82   
 Well   Reference  
 Moderate   1.29 (0.38–4.35)  
 Poorly   0.98 (0.26–3.74)  
Maximum diameter of tumor  < 0.01 1.43 (1.14–1.80)  < 0.01 1.46 (1.11–1.92)
Depth of tumor invasion 0.06   
 T1   0.37 (0.08–1.75)  
 T2   Reference  
 T3   1.51 (0.50–4.61)  
 T4   2.29 (0.58–9.02)  
PLN status  < 0.01    < 0.01  
 Negative   Reference   Reference
 Positive   4.80 (2.01–11.43)   3.94 (1.45–10.68)
MLN status  < 0.01   
 Negative   Reference  
 Positive   3.88 (1.51–9.98)  
RLN LN status  < 0.01    < 0.01  
 Negative   Reference   Reference
 Positive   5.05 (2.26–11.30)   3.82 (1.56–9.34)
ALN status 0.84   
 Negative   Reference  
 Positive   1.14 (0.51–2.54)  
Blood vessel invasion 0.12   
 Negative   Reference  
 Positive   2.66 (0.91–7.75)  
Nerve invasion 0.29   
 Negative   Reference  
 Positive   1.77 (0.68–4.61)  
CT-reported cervical LN status  < 0.01    < 0.01  
 Negative   Reference   Reference
 Positive   3.41 (1.46–7.94)   4.43 (1.60–12.27)
  1. OR odds ratio, CI confidence interval