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Table 4 Sensitivity and specificity data for faecal calprotectin in colorectal cancer

From: The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis

Author Year n Cut-off Standard-ised cut-off Sens (%) Spec (%) PPV (%) NPV (%) Comment
Total CRC (%)
Kronborg 2000 814 23 (2.8) 10 mg/l 50 74.0  
Tibble 2001 233 62 (26.6) 10 mg/l 50 90.0  
Hoff 2004 2321 16 (0.7) 50 μg/g 50 72.7* 76.1* 4.2* 99.5*  
Damms 2008 140 8 (5.7) 50 μg/g 50 100 79.0 40.0 100  
Meucci 2010 870 34 (3.9) 50 mg/dl   85.0 58.0 6.0 99.0  
Kalimutho 2011 192 28 (14.6) 45 .8 ng/ml   72.0 75.0 43.0* 91.0*  
Parente 2012 280 47 (16.8) 50 μg/g 50 85.7 39.7 22.2 93.3  
     416 μg/g 416 43.2 88.8 44.2 88.4  
Khoshbaten 2014 150 50 (33.3) 75.8 μg/g 75.8 80.0 84.0  
Mowat 2015 755 28 (3.7) 50 μg/g 50 82.1 38.8 5.1 98.2  
     200 μg/g 200 46.4 74.9 6.9 97.2  
Rutka 2016 95 19 (20.0) 128.5 μg/g 128.5 77.8 70.0 53.8 87.5  
Turvill 2016 654 39 (6.0) 50 μg/g 50 92.7 35.2 8.7 98.6  
Widlak 2016 430 24 (5.6) 50 μg/g 50 68.0 84.0 21.0* 98.0* Total number for this analysis is 25 CRC (including 1 HGD)
Hogberg 2017 373 8 (2.1) 20 μg/g 20 100 51.5 4.3 100  
     50 μg/g 50 87.5 72.1 6.4 99.6  
     100 μg/g 100 50.0 85.2 6.9 98.7  
Turvill 2018 515 27 (5.2) 10 μg/g 10 74.1 66.3 10.9 97.9 For a single FC
Lue 2020 404 16 (4) 50 μg/g 50 75 48.2 5.6 97.9  
  1. *Calculated value, CRC colorectal cancer, PPV positive predictive value, NPV negative predictive value