Table 4 Sensitivity and specificity data for faecal calprotectin in colorectal cancer
Author | Year | n | Cut-off | Standard-ised cut-off | Sens (%) | Spec (%) | PPV (%) | NPV (%) | Comment | |
|---|---|---|---|---|---|---|---|---|---|---|
Total | CRC (%) | |||||||||
Kronborg | 2000 | 814 | 23 (2.8) | 10 mg/l | 50 | 74.0 | – | – | – |  |
Tibble | 2001 | 233 | 62 (26.6) | 10 mg/l | 50 | 90.0 | – | – | – |  |
Hoff | 2004 | 2321 | 16 (0.7) | 50 μg/g | 50 | 72.7* | 76.1* | 4.2* | 99.5* |  |
Damms | 2008 | 140 | 8 (5.7) | 50 μg/g | 50 | 100 | 79.0 | 40.0 | 100 |  |
Meucci | 2010 | 870 | 34 (3.9) | 50Â mg/dl | Â | 85.0 | 58.0 | 6.0 | 99.0 | Â |
Kalimutho | 2011 | 192 | 28 (14.6) | 45 .8Â ng/ml | Â | 72.0 | 75.0 | 43.0* | 91.0* | Â |
Parente | 2012 | 280 | 47 (16.8) | 50 μg/g | 50 | 85.7 | 39.7 | 22.2 | 93.3 |  |
|  |  |  |  | 416 μg/g | 416 | 43.2 | 88.8 | 44.2 | 88.4 |  |
Khoshbaten | 2014 | 150 | 50 (33.3) | 75.8 μg/g | 75.8 | 80.0 | 84.0 | – | – |  |
Mowat | 2015 | 755 | 28 (3.7) | 50 μg/g | 50 | 82.1 | 38.8 | 5.1 | 98.2 |  |
|  |  |  |  | 200 μg/g | 200 | 46.4 | 74.9 | 6.9 | 97.2 |  |
Rutka | 2016 | 95 | 19 (20.0) | 128.5 μg/g | 128.5 | 77.8 | 70.0 | 53.8 | 87.5 |  |
Turvill | 2016 | 654 | 39 (6.0) | 50 μg/g | 50 | 92.7 | 35.2 | 8.7 | 98.6 |  |
Widlak | 2016 | 430 | 24 (5.6) | 50 μg/g | 50 | 68.0 | 84.0 | 21.0* | 98.0* | Total number for this analysis is 25 CRC (including 1 HGD) |
Hogberg | 2017 | 373 | 8 (2.1) | 20 μg/g | 20 | 100 | 51.5 | 4.3 | 100 |  |
|  |  |  |  | 50 μg/g | 50 | 87.5 | 72.1 | 6.4 | 99.6 |  |
|  |  |  |  | 100 μg/g | 100 | 50.0 | 85.2 | 6.9 | 98.7 |  |
Turvill | 2018 | 515 | 27 (5.2) | 10 μg/g | 10 | 74.1 | 66.3 | 10.9 | 97.9 | For a single FC |
Lue | 2020 | 404 | 16 (4) | 50 μg/g | 50 | 75 | 48.2 | 5.6 | 97.9 |  |