The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis

Ross, Fiona A.; Park, James H.; Mansouri, David; Combet, Emilie; Horgan, Paul G.; McMillan, Donald C.; Roxburgh, Campbell S. D.

doi:10.1186/s12876-022-02220-1

Table 1 Studies reporting faecal calprotectin assays in the context of colorectal neoplasia

From: The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis

References	Year	Manufacturer	Test	Units	Cut-off	Standardised cut-off
Roseth [18]	1992		EIA	μg/l
Roseth [21]	1993		EIA	mg/l	10 mg/l	50
Gilbert [22]	1996	Nycomed Pharma	ELISA	mg/l	10 mg/l	50
Kristinsson [23]	1998		EIA	mg/l	10 mg/l	50
Kronborg [24]	2000	Nycomed Pharma	ELISA, PhiCal	mg/l	10 mg/l	50
Ton [11]	2000	Nycomed Pharma	ELISA, PhiCal	mg/l	10 mg/l	50
Kristinsson [16]	2001	Nycomed Pharma	ELISA, PhiCal	mg/l	10 mg/l	50
Tibble [25]	2001		ELISA	mg/l	10 mg/l	50
Kristinsson [26]	2001	Nycomed Pharma	ELISA, PhiCal	mg/l	10 mg/l	50
Summerton [27]	2002	Nycomed	ELISA, PhiCal	mg/l	10 mg/l	50
Tibble [28]	2002		ELISA	mg/l	10 mg/l	50
Costa [29]	2003	Eurospital	ELISA, Calprest	μg/g	50 μg/g	50
Limburg [30]	2003	Nycomed Pharma	ELISA	μg/g	50 μg/g	50
Hoff [31]	2004	Nycomed Pharma	ELISA, PhiCal	μg/g	50 μg/g	50
Chung-Faye [32]	2007		ELISA	μg/g	25 μg/g	25
Damms[33]	2008	Bühlmann	ELISA	μg/g	50 μg/g	50
Karl [34]	2008	NovaTec	ELISA	μg/g
Meucci [35]	2010	Eurospital	ELISA, Calprest	mg/dl	50 mg/dl
Kalimutho [36]	2011	Eurospital	ELISA, Calprest	ng/ml	45.8 ng/ml
Kok [37]	2012	Bühlmann	ELISA, EK-CAL	μg/g	50 μg/g	50
Manz [38]	2012	Bühlmann	ELISA	μg/g	50 μg/g	50
Parente [39]	2012	Bühlmann	ELISA	μg/g	50 μg/g	50
Pavlidis [40]	2013	Bühlmann	ELISA, EK-CAL	μg/g	50 μg/g	50
Khoshbaten [41]	2014	Bühlmann	ELISA	μg/g	75.8 μg/g	75.8
Lehmann [42]	2014	Viollier	ELISA	μg/g	50 μg/g	50
Wang [43]	2014	Labsystem	ELISA	IU/ml
Borza [44]	2015	Sofar Farmaceutici	Cal-Detect SOFAR (Semi-quantitative)	mg/g	15 mg/g
Mowat [45]	2015	Bühlmann	ELISA, EK-CAL	μg/g	50 μg/g	50
Cubiella [46]	2016	Bühlmann	ELISA, fCAL	ng/ml
Rutka [47]	2016	Bühlmann	Quantum Blue	μg/g	128.5 μg/g	128.5
Turvill [48]	2016	Bühlmann	ELISA, EK-CAL	μg/g	50 μg/g	50
Widlak [49]	2016	Thermo Fisher Scientific	ELISA, EliA	μg/g	50 μg/g	50
Hogberg [50]	2017	Calpro AS	ELISA, CALPRO	μg/g	100 μg/g	100
Turvill [51]	2018	Bühlmann	ELISA, EK-CAL	μg/g	10 μg/g	10
Lue [52]	2020	Thermo Fisher Scientific	ELISA, EliA	μg/g	50 μg/g	50

EIA enzyme immunoassay, ELISA enzyme-linked immunosorbent assay, mg/l milligrams/litre, mg/dl milligrams/ desilitre, μg/g microgram/gram, ng/ml nanogram/millilitre, IU/ml international unit/millilitre, Standardised Cut-off μg/g or mg/l multiplied by 5

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ISSN: 1471-230X

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