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Table 2 Previous cases of PI/PCI post etoposide-based chemotherapy

From: Pneumatosis cystoides intestinalis associated with etoposide in hematological malignancies: a case report and a literature review

Case [Ref.]

Sex/Age (yr)

Underlying disease

Chemotherapy

Causative agent, dose

Location

Diagnostic tools

Associated symptoms

Complications

Treatments

Outcome

Time to recovery

1 [29]

M/58

Lymphoma

NA

Etoposide, NA

Total colon

X-ray + CT

None

No

Parenteral nutrition antibiotics

Resolved

30 days

2 [32]

M/51

Lymphoma

MNCOP-V

Etoposide, 100 mg

Total colon

X-ray

Septicemia and abdominal discomfort

No

Oxygen therapy parental nutrition antibiotics

Resolved

NA

3 [32]

F/58

Lymphoma

MNCOP-V

Etoposide, 95 mg

Total colon + terminal ileum

X-ray

Slight abdominal distension

No

Oxygen therapy parental nutrition

Resolved

1 week

4 [32]

M/74

AML-M2

NA

Etoposide, NA

Total colon

X-ray

Abdominal distension

No

Oxygen therapy parental nutrition

Resolved

2 weeks

5 [34]

F/53

Breast cancer

Various

Etoposide, 50 mg qd

Total colon + rectum

X-ray + CT + colonoscopy

Severe abdominal distension with decreased flatus

No

Oxygen therapy antibiotics

Resolved

3 weeks

6 [35]

M/69

Small cell lung cancer

Carboplatin (d1) + etoposide (d1–3)

Etoposide, 100 mg

Sigmoid colon + retroperitoneum + posterior mediastinum

CT

Abdominal distension

No

Oxygen therapy antibiotics

Resolved

2 weeks

  1. M male, F female, AML acute myeloid leukemia, MNCOP-V methotrexate with leucovorin rescue, mitoxantrone, cyclophosphamide, vincristine, prednisolone and etoposide, NA not available