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Table 1 Case reports of adult-onset OTC deficiency induced by corticosteroids

From: Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency

n

Ref

Age

M/F

Primary disease

Steroid

Max NH3 (µg/dL)

Symptom

Onset (days)

Treatment

Outcome

1

[6]

67

M

NSIP

Predonisone

4257

Seizure

Dead

2

[7]

56

M

Glottic edema

Unknown

320

Coma

4

HD

Alive

3

[8]

24

M

Deviated septum

Dexamethasone 8 mg/day

885

Vagueness

2

Dead

4

[8]

39

M

Knee arthritis

Cortisone

1124

Headache, nausea

2

Dead

5

[22]

45

M

Knee arthritis

Cortisone

700

Coma

9

Dead

6

[23]

36

M

Hearing defect

Predonisone 60 mg/day

1185

Coma

14

P + B

Alive

7

[24]

26

F

Preterm labor

Betamethasone

507

Coma

4

B + CHDF

Alive

8

[25]

58

F

Asthma

Methylprednisolone

477

Coma

5

P + B + HD

Alive

9

[26]

19

M

Leukoplakia

Betamethasone 1 mg/day

 > 500

Coma

56

Dead

10

This report

45

M

Meniere’s disease

Predonisone 60 mg/day

784

Disorientation

5

HF-CHDF

Alive

11

This report

30

M

Asthma

Predonisone 30 mg/day

423

Disorientation

7

CHDF

Alive

  1. M male, F female, NSIP nonspecific interstitial pneumonia, P phenylbutyrate, B benzoate, HD hemodialysis, HF-CHDF high-flow continuous hemodiafiltration