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Table 1 Case reports of adult-onset OTC deficiency induced by corticosteroids

From: Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency

n Ref Age M/F Primary disease Steroid Max NH3 (µg/dL) Symptom Onset (days) Treatment Outcome
1 [6] 67 M NSIP Predonisone 4257 Seizure Dead
2 [7] 56 M Glottic edema Unknown 320 Coma 4 HD Alive
3 [8] 24 M Deviated septum Dexamethasone 8 mg/day 885 Vagueness 2 Dead
4 [8] 39 M Knee arthritis Cortisone 1124 Headache, nausea 2 Dead
5 [22] 45 M Knee arthritis Cortisone 700 Coma 9 Dead
6 [23] 36 M Hearing defect Predonisone 60 mg/day 1185 Coma 14 P + B Alive
7 [24] 26 F Preterm labor Betamethasone 507 Coma 4 B + CHDF Alive
8 [25] 58 F Asthma Methylprednisolone 477 Coma 5 P + B + HD Alive
9 [26] 19 M Leukoplakia Betamethasone 1 mg/day  > 500 Coma 56 Dead
10 This report 45 M Meniere’s disease Predonisone 60 mg/day 784 Disorientation 5 HF-CHDF Alive
11 This report 30 M Asthma Predonisone 30 mg/day 423 Disorientation 7 CHDF Alive
  1. M male, F female, NSIP nonspecific interstitial pneumonia, P phenylbutyrate, B benzoate, HD hemodialysis, HF-CHDF high-flow continuous hemodiafiltration