Fig. 2
The levels of hepatic metabolites from WT and Otcspf−ash mice that were administered DEX or NS. a Heat map analysis of metabolomics. It was generated by coloring the values of all data across their respective ranges. The color red indicates that the relative content of metabolites is high, while green indicates that they are low. The brightness of each color corresponds to the magnitude of the difference between the observed value and the average value. b The amounts of urea-cycle-related metabolites in WT and Otcspf−ash mice, normalized to those in WT-NS were presented as mean ± SD. ∗ p < 0.05 and ∗ ∗p < 0.01. ASS1, arginosuccinate synthase 1; ASL, arginosuccinate lyase; ARG1, arginase 1; ORNT1, mitochondrial ornithine transporter 1; OTC, ornithine transcarbamylase; CPS1, carbamoyl-phosphate synthase 1. NS; normal saline, DEX; dexamethasone