Fig. 1
The time-course of serum ammonia levels. The blood samples were collected at 0, 24, and 48 h after the first DEX administration. Ammonia levels at 24 h after DEX administration were increased in the Otcspf−ash-DEX group (P < 0.05; vs. dex-matched controls, P = 0.06; vs. genotype-matched controls). Ammonia levels at 48 h after DEX administration were further increased in the Otcspf−ash-DEX group (P = 0.06; vs. dex-matched controls, P < 0.05; vs. genotype-matched controls). Data are expressed as the mean ± SD. WT-NS and WT-DEX, n = 3/group; Otcspf−ash- NS and Otcspf−ash-DEX, n = 5/group. †P < 0.05; vs. dex-matched controls, *P < 0.05; vs. genotype-matched controls. NS; normal saline, DEX; dexamethasone