Table 3 Univariate and multivariate analyses of different parameters for PFS

Age (years)

 < 60

1

 ≥ 60

0.13

0.87–3.06

Gender

 Female

1

 Male

0.48

0.67–2.39

Tumor location

 Right

1

 Left

0.08

0.20–1.10

Histological grade

 Well + moderate

1

 Poor

0.29

0.71–3.11

CEA status

 Normal

1

 Elevated

0.02

1.16–3.85

Invasive depth

 T₁₊₂

1

 T₃₊₄

0.02

1.26–9.86

Tumor diameter (cm)

 < 4

1

 ≥ 4

0.36

0.72–2.51

Node involvement

 N₀

1

 N₁₊₂

< 0.01

1.24–4.16

Distant metastasis

 M0

1

1

 M1

< 0.01

4.87–23.73

< 0.01

3.88–19.49

TNM stage

 I + II

1

 II + IV

< 0.01

1.41–4.88

BMI (kg/m²)

0.23

0.86–1.04

Preoperative measures

 NLR

0.09

0.99–1.15

 LMR

0.04

0.66–0.99

 PNI

< 0.01

0.88–0.97

< 0.01

0.89–0.98

Tregs intratumor

< 0.01

0.95–0.99

< 0.01

0.95–0.99

Tregs in TDLNs

0.77

0.99–1.01