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Table 5 Relation between alcohol abstinence and risk of HCC in ALD, ALD + HBV and ALD + HCV patients

From: Effect of alcohol on clinical complications of hepatitis virus-induced liver cirrhosis: a consecutive ten-year study

 

Without HCC

With HCC

ULR

MLR

n (%)

n (%)

P value

OR(95% CI)

P value

ALD

     
   

0.001

  

No abstinence

942 (63.6)

131 (77.1)

 

1

 

Abstinent < 5 years

156 (10.5)

18 (10.6)

 

0.71 (0.40–1.24)

0.226

Abstinent 5–10 years

136 (9.20)

9 (5.30)

 

0.37 (0.18–0.77)

0.008

Abstinent > 10 years

248 (16.7)

12 (7.10)

 

0.27 (0.14–0.50)

<  0.001

ALD + HBV

     
   

<  0.001

  

No abstinence

370 (48.6)

684 (82.2)

 

1

 

Abstinent < 5 years

163 (21.4)

98 (11.8)

 

0.10 (0.04–0.24)

<  0.001

Abstinent 5–10 years

111 (14.6)

34 (4.1)

 

0.01 (0.00–0.04)

<  0.001

Abstinent > 10 years

118 (15.5)

16 (1.9)

 

0.01 (0.00–0.03)

<  0.001

ALD + HCV

     
   

<  0.001

  

No abstinence

119 (64.7)

85 (89.5)

 

1

 

Abstinent < 5 years

38 (20.5)

7 (7.4)

 

0.26 (0.10–0.68)

0.010

Abstinent 5–10 years

15 (8.1)

2 (2.1)

 

0.17 (0.03–0.84)

0.037

Abstinent > 10 years

13 (7.1)

1 (1.1)

 

0.10 (0.01–0.82)

0.047

  1. ULR, univariate logistic regression; MLR, multivariate logistic regression; HCC, Hepatocellular carcinoma; EGVB, Esophageal gastric variceal bleeding. The logistic regression analysis in ALD group was adjusted for age, alcoholism duration, presence of decompensation, MCV, ALT, presence of infection, hepatic encephalopathy, thrombus, and child classification. In ALD + HBV group, the analysis was adjusted for age, alcoholism duration, MCV, GGT, presence of diabetes, presence of decompensation, infection, HE, thrombus, HRS, EGVB and child classification. In ALD + HCV group, the analysis was adjusted for age, sex, alcoholism duration, presence of decompensation, thrombus, infections and MCV. See Additional file: Tables S5, S7 and S9 for detailed results