Table 3 Univariate and multivariate logistic regression evaluating factors associated with HCC in ALD, HBV and ALD + HBV patients
Factors | Without HCC | With HCC | ULR | MLR | |
|---|---|---|---|---|---|
n (%) | n (%) | P value | OR (95% CI) | P value | |
Sex (male) | 10,298 (81.1) | 7797 (90.4) | < 0.001 | 2.55 (1.95–3.34) | <  0.001 |
Age (> 50y) | 6861 (54.0) | 5481 (63.6) | < 0.001 | 1.79 (1.54–2.09) | <  0.001 |
Etiologies |  |  | < 0.001 |  |  |
HBV | 10,457 (82.3) | 7622 (88.4) | Â | 1 | Â |
ALD | 1482 (11.7) | 170 (2.0) |  | 0.18 (0.12–0.26) | <  0.001 |
ALD + HBV | 762 (6.0) | 832 (9.6) |  | 2.01 (1.58–2.55) | <  0.001 |
T2DM | 1726 (14.4) | 757 (9.2) | <  0.001 | 0.41 (0.32–0.52) | <  0.001 |
Decomp. Sx | 6657 (52.4) | 2245 (26.0) | <  0.001 | 0.59 (0.48–0.73) | <  0.001 |
Infection | 3906 (30.8) | 1317 (15.3) | <  0.001 | 0.70 (0.58–0.84) | <  0.001 |
Ascites | 6153 (48.4) | 3453 (40.0) | <  0.001 | 1.85 (1.54–2.22) | <  0.001 |
HE | 1014 (8.0) | 164 (1.9) | <  0.001 | 0.62 (0.43–0.89) | 0.010 |
Thrombus | 670 (5.3) | 552 (6.4) | 0.001 | 1.47 (1.09–1.98) | 0.011 |
HRS | 282 (2.2) | 78 (0.90) | <  0.001 |  |  |
EGVB | 1801 (34.1) | 813 (28.5) | <  0.001 | 1.46 (1.19–1.80) | <  0.001 |
Child classification |  |  | <  0001 |  |  |
 A | 4059 (32.9) | 4887 (57.8) |  | 1 |  |
 B | 4914 (39.8) | 2759 (32.6) |  | 0.66 (0.54–0.81) | <  0.001 |
 C | 3363 (27.3) | 814 (9.6) |  | 0.41 (0.31–0.54) | <  0.001 |
MCV > 100 | 1758 (13.9) | 673 (7.9) | <  0.001 |  |  |
ALT > 40 | 6770 (53.8) | 4617 (54.0) | 0.856 |  |  |
AST > 40 | 6584 (92.8) | 4287 (90.1) | <  0.001 |  |  |
GGT > 60 | 4753 (67.7) | 4012 (85.0) | <  0.001 | 4.00 (3.31–4.82) | <  0.001 |