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Table 1 Liver function characteristics of the studied groups

From: Effect of alcohol on clinical complications of hepatitis virus-induced liver cirrhosis: a consecutive ten-year study

Parameters

ALD

n = 1652

HBV

n = 18,079

HCV

n = 682

ALD + HBV

n = 1594

ALD + HCV

n = 280

P value

Sex: male

1611 (97.5%)

14,914 (82.5%)a

391 (57.3%)a,b,d

1570 (98.5%)b

258 (92.1%)a,b,c,d

< 0.001

Age (years): median (P25, P75)

52 (46, 59)

52 (44, 61)

55 (47, 64)a,b,d

53 (46, 60)

46 (41, 53)a,c,d

< 0.001

Decompensation

975 (59.0)

7039 (38.9)a

221 (32.4)a,b

888 (55.7)b,c

152 (54.3)b,c

< 0.001

MCV (fl)

93.7 (84.4, 101.1)

90.1 (84.2, 94.9)a

91.3 (85.4, 95.8)a,d

92.6 (85.9, 98.3)b

93.8 (85.6, 100)b,c,d

< 0.001

ALT (U/L)

34 (22, 55)

44 (28, 85)a

47 (28, 79)a,d

51 (31, 94)a,b

43 (29, 76)a,b,d

< 0.001

AST (U/L)

65 (40, 108)

58 (35, 117)

63 (38, 99)d

83 (47, 158)a,b

79 (50, 141)a,b,c

< 0.001

AST/ALT

1.9 (1.3, 2.7)

1.3 (0.9, 1.8)a

1.3 (1.0, 1.8)a,d

1.5 (1.1, 2.2)a,b

1.7 (1.3, 2.5)b,c,d

< 0.001

GGT (U/L)

169 (66, 364)

72 (37, 153)a

55 (32, 114)a,b,d

137 (65, 274)b

119 (58, 229)a,b,c

< 0.001

MELD score

11.4 (7.0, 17.7)

9.2 (5.7, 15.2)a

7.3 (4.3, 11.2)a,b,d

11.1 (6.7, 17.7)b

10.0 (7.0, 14.7)c

< 0.001

MELD ≥ 18

389 (24.3%)

3257 (18.5%)a

50 (7.6%)a,b,d

379 (24.1%)b

36 (13.1%)a,d

< 0.001

GAHS

7.0 (6.0, 8.0)

7.0 (6.0, 7.0)a

6.0 (6.0, 7.0)a,b,d

7.0 (6.0, 8.0)b

6.0 (5.0, 7.0)a,b,d

< 0.001

GAHS ≥ 9

238 (14.8%)

2014 (11.5%)a

22 (3.3%)a,b,d

222 (14.1%)b

20 (7.3%)a,d

< 0.001

MDF score

23.7 (13.3, 41.0)

18.8 (11.0, 34.6)a

16.1 (10.7, 25.2)a,b,d

22.4 (12.6, 40.3)a,b

20.3 (13.3, 33.5)c

< 0.001

MDF ≥ 32

579 (36.1%)

4883 (27.7%)a

102 (15.5%)a,b,d

430 (33.7%)b

73 (26.5%)a,c

< 0.001

Child A

413 (25.7%)

8044 (45.7%)a

351 (53.4%)a,b,d

489 (31.1%)a,b

83 (30.3%)b,c,d

< 0.001

Child B

758 (47.3%)

6271 (40.9%)a

242 (36.8%)a,b,d

644 (40.9%)a,b

141 (51.5%)b,c,d

< 0.001

Child C

433 (27.0%)

3304 (18.8%)a

64 (9.7%)a,b,d

440 (28.0%)a,b

50 (18.2%)b,c,d

< 0.001

  1. Values are expressed in median (25th, 75th percentiles) unless indicated otherwise
  2. MCV, Mean Corpuscular Volume; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, Gamma-glutamyl transferase; MELD score, Model for End-stage Liver Disease; GAHS, Glasgow Alcoholic Hepatitis Score; MDS, Maddrey’s Discriminant function Scale. MELD ≥ 18, GAHS ≥ 9 and MDF ≥ 32 represent proportion of patients with MELD, GAHS and MDF greater or equal to 18, 9 and 32 respectively. Child A, B, C represents respectively proportion of Child–Pugh A, B and C classification patients with complete data
  3. aMeans value statistically significant compared to that in ALD; bmeans value statistically significant compared to that in HBV; cmeans value statistically significant compared to that in HCV; dmeans value statistically significant compared to that in HBV + ALD. Bonferroni correction was used for “P” during pairwise comparisons