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Table 5 Sensitivity and specificity of reflux seen on high resolution esophageal manometry with impedance testing for gastroesophageal reflux disease as diagnosed by ambulatory pH monitoring with impedance testing or Bravo capsule

From: Characterizing reflux on high resolution esophageal manometry with impedance

# of swallows on HREMI with reflux

All patients

(n = 229)

Patients on PPI

(n = 141)

Patients off PPI

(n = 88)

Sensitivity (%)

Specificity (%)

Sensitivity (%)

Specificity (%)

Sensitivity (%)

Specificity (%)

1

39.8

75.0

42.3

70.0

35.7

82.6

2

24.8

83.6

25.4

80.0

23.8

89.1

3

20.4

87.1

21.1

81.4

19.0

95.7

4

15.9

88.8

16.9

84.3

14.3

95.7

5

14.2

91.4

14.1

87.1

14.3

95.7

6

12.4

93.1

11.3

90.0

14.3

97.8

7

9.7

95.7

8.5

94.3

11.9

97.8

8

7.1

97.4

8.5

97.1

11.9

97.8

9

6.2

97.4

7.0

97.1

11.9

97.8

10

5.3

97.4

5.6

97.1

11.9

97.8

11

5.3

98.3

5.6

98.6

4.8

97.8

12

1.8

98.3

2.8

98.6

0

97.8

  1. AET Acid Exposure Time, BID twice daily, HREMI High Resolution Esophageal Manometry with Impedance, PPI Proton Pump Inhibitor, QD once daily