Investigating the effect of quadruple therapy with Saccharomyces boulardii or Lactobacillus reuteri strain (DSMZ 17648) supplements on eradication of Helicobacter pylori and treatments adverse effects: a double-blind placebo-controlled randomized clinical trial

Table 2 Generalized estimating equations (GEE) logistic model of the association between the treatment group and complications

Outcome	Variables		Coefficient	SE	P value	OR
Nausea	Treatment group	S	0.90	0.36	0.01	2.47
	Base line: control group	P	0.41	0.36	0.26	1.52
	Time		1.51	0.14	< 0.001	4.55
Diarrhea	Treatment group	S	1.10	0.49	0.02	3.01
	Base line: control group	P	0.63	0.51	0.21	1.89
	Time		1.74	0.16	< 0.001	5.74
Headache	Treatment group	S	2.35	0.65	< 0.001	10.51
	Base line: control group	P	1.32	0.55	0.01	3.75
	Time		1.08	0.26	< 0.001	2.95
Abdominal pain	Treatment group	S	1.16	0.54	0.03	3.21
	Base line: control group	P	0.39	0.43	0.36	1.48
	Time		1.14	0.17	< 0.001	3.14
Anxiety	Treatment group	S	1.27	0.56	0.02	3.58
	Base line: control group	P	− 0.38	0.46	0.40	0.68
	Time		0.61	0.12	< 0.001	1.86

ISSN: 1471-230X