Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in children

BMC Gastroenterology

Table 2 Serum ceruloplasmin levels in WD children with different manifestations at diagnosis

WD patients	Cp (mg/dL)	Age (years)	No. of patients
WD patients	Cp (mg/dL)	Age (years)	Total	0–5	5–10	10–15	15–20	≥ 20
Asymptomatic WD	5.5 ± 4.6^a	5.4 ± 2.3^b	261	157	67	22	9	6
Symptomatic WD	7.0 ± 4.8	9.4 ± 2.6	56	27	11	14	4	0
WD w/o ALF	5.6 ± 4.6^c	6.0 ± 2.8^d	302	180	75	30	11	6
WD w/ ALF	9.3 ± 4.7	9.0 ± 2.2	15	4	3	6	2	0
Total	5.7 ± 4.7	5.7 ± 4.7	317	184	78	36	13	6

WD, Wilson’s disease; ALF, acute liver failure
^aRepresents comparison of serum ceruloplasmin in asymptomatic WD with symptomatic WD children, p value < 0.05
^bRepresents comparison of age in asymptomatic WD with symptomatic WD children, p value < 0.001
^cRepresents comparison of serum ceruloplasmin between WD children with and without acute liver failure, p value < 0.01
^dRepresents comparison of age between WD children with and without acute liver failure, p value < 0.001

ISSN: 1471-230X