Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in children

BMC Gastroenterology

Table 1 Serum ceruloplasmin levels in healthy children and WD patients stratified by age

Age group	Healthy children							WD patients							p value
Age group	Cp(mg/dL)	Number	0–5	5–10	10–15	15–20	≥ 20	Cp(mg/dL)	Number	0–5	5–10	10–15	15–10	≥ 20	p value
< 6 mths	25.5 ± 10.1	20	0	1	3	2	14	–	–	–	–	–	–	–	–
6 mths-	33.0 ± 9.3	20	0	0	1	2	17	4.0	1	1	0	0	0	0	–
1 yr-	31.5 ± 8.0	28	0	0	0	3	25	3.3 ± 2.2	4	3	1	0	0	0	p < 0.001
2 yrs-	30.0 ± 8.3	22	0	1	1	0	20	4.6 ± 3.3	19	13	5	0	1	0	p < 0.001
3 yrs-	32.0 ± 6.4	24	0	0	0	1	23	5.2 ± 5.1	51	33	12	3	0	3	p < 0.001
4 yrs-	33.7 ± 6.5	25	0	0	0	0	25	5.6 ± 4.4	59	35	15	5	3	1	p < 0.001
5 yrs-	31.7 ± 5.7	35	0	0	0	1	34	6.5 ± 5.6	48	25	12	8	1	2	p < 0.001
6 yrs-	33.7 ± 5.0	26	0	0	0	0	26	6.3 ± 5.1	38	20	10	5	3	0	p < 0.001
7 yrs-	31.6 ± 5.3	25	0	0	0	0	25	5.3 ± 3.7	25	16	4	5	0	0	p < 0.001
8 yrs-	30.9 ± 5.9	27	0	0	0	1	26	6.2 ± 4.8	20	10	6	2	2	0	p < 0.001
9 yrs-	28.9 ± 6.3	22	0	0	0	2	20	7.6 ± 5.2	8	3	3	1	1	0	p < 0.001
10 yrs-	29.1 ± 9.8	21	0	0	3	2	16	6.5 ± 4.5	17	9	4	2	2	0	p < 0.001
11 yrs-	27.5 ± 7.7	23	0	1	1	0	21	6.3 ± 3.2	9	4	3	2	0	0	p < 0.001
12 yrs-	32.4 ± 8.8	25	0	0	0	0	25	4.9 ± 3.2	13	9	2	2	0	0	p < 0.001
13 yrs-	26.3 ± 6.2	16	0	0	0	1	15	6.4 ± 4.3	3	1	1	1	0	0	p < 0.001
14 yrs-	29.1 ± 9.7	13	0	0	1	2	10	3.0 ± 1.0	2	2	0	0	0	0	p = 0.003
Total	30.7 ± 7.8	372	0	3	10	17	342	5.7 ± 4.7	317	184	78	36	13	6	p < 0.001

Cp, ceruloplasmin; 0–5, 5–10, 10–15, 15–20 and ≥ 20 represented the ranges of serum ceruloplasmin (mg/dL); Number represented the number of the children with specific range of serum ceruloplasmin

ISSN: 1471-230X