Fig. 2

Receiver operating characteristic (ROC) curves of serum ceruloplasmin for the diagnosis of Wilson’ disease (WD). A When analyzing WD patients together with heterozygotes and non-WD patients, the area under the curve (AUC) was 0.990 (95% confidence interval (CI), 0.985–0.995). B When analyzing WD patients with acute liver failure and non-WD patients with acute liver failure, the area under the curve was 0.952 (95% confidence interval (CI), 0.885–1). C When analyzing asymptomatic WD patients and non-WD patients with viral hepatitis, the area under the curve was 0.994 (95% confidence interval (CI), 0.988–1). D–F Box and whisker plots show the values of serum ceruloplasmin in all WD and non-WD patients (D), the patients with acute liver failure and the patients (E) with elevated aminotransferases (F). The black line represents the consensus cutoff of serum ceruloplasmin (20 mg/dL). The dash lines in D–F represent the cutoff values obtained in the ROC curves of A–C (16.9 mg/dL, 16.0 mg/dL and 16.9 mg/dL), respectively.