Table 3 Prognostic factors related to early recurrence by logistic regression analysis

Age (years old)

1.01 (0.99–1.03)

0.206

Sex (male/female)

1.84 (1.21–2.78)

0.004

1.68 (1.07–2.65)

0.024

Hypertension (yes/no)

0.91 (0.63–1.33)

0.636

Diabetes mellitus (yes/no)

1.10 (0.72–1.66)

0.671

Smoking history (yes/no)

1.36 (0.99–1.88)

0.060

Drinking history (yes/no)

1.26 (0.90–1.77)

0.171

Antivival history (yes/no)

0.73 (0.52–1.00)

0.051

Etiology (HBV/HCV/Co-infection/others)

0.95 (0.78–1.15)

0.582

Cirrhosis (yes/no)

1.85 (1.19–2.88)

0.007

1.68 (1.01–2.79)

0.047

Child–Pugh class (A/B)

1.46 (1.01–2.10)

0.043

1.08 (0.67–1.74)

0.749

Fractional ablation (yes/no)

2.18 (1.34–3.54)

0.002

1.07 (0.61–1.88)

0.814

Ablative.modality (RFA/MWA/AHC)

0.95 (0.78–1.15)

0.582

Tumor number (single/multiple)

2.08 (1.47–2.94)

 < 0.001

1.99 (1.34–2.96)

0.001

Tumor size (≤ 30 mm/ > 30 mm)

2.36 (1.65–3.37)

 < 0.001

2.22 (1.47–3.36)

 < 0.001

Alanine aminotransferase (U/L)

1.01 (1.00–1.01)

0.096

Aspartate aminotransferase (U/L)

1.02 (1.01–1.02)

0.002

1.01 (1.00–1.02)

0.064

Total bilirubin (μmol/L)

1.02 (1.01–1.04)

0.005

1.01 (0.98–1.03)

0.576

Albumin (g/l)

0.94 (0.91–0.98)

0.001

1.00 (0.95–1.04)

0.827

INR

3.83 (1.02–14.41)

0.047

1.07 (0.17–6.67)

0.945

Alpha fetoprotein (< 7/7–400/ > 400 ng/mL)

1.45 (1.12–1.88)

0.005

1.20 (0.90–1.62)

0.221

Viral load (< 1000/1000–20,000/ > 20000 IU/mL)

1.28 (1.05–1.57)

0.015

1.10 (0.87–1.34)

0.427

MLR

3.93 (1.82–8.49)

 < 0.001

2.94 (1.28–6.77)

0.011