Table 2 Prognostic factors associated with OS by Cox proportional hazards regression model

Age (years old)

1.02 (1.01–1.04)

0.005

1.03 (1.01–1.04)

0.005

Sex (male/female)

1.56 (1.06–2.30)

0.024

1.18 (0.75–1.84)

0.481

Hypertension (yes/no)

0.88 (0.63–1.22)

0.430

Diabetes mellitus (yes/no)

1.11 (0.79–1.57)

0.553

Smoking history (yes/no)

1.41 (1.08–1.85)

0.012

1.22 (0.88–1.68)

0.230

Drinking history (yes/no)

1.64 (1.25–2.15)

 < 0.001

1.61 (1.17–2.22)

0.004

Antivival history (yes/no)

0.73 (0.56–0.96)

0.024

0.91 (0.67–1.25)

0.574

Etiology (HBV/HCV/co-infection/others)

1.17 (1.04–1.32)

0.008

1.13 (0.98–1.30)

0.103

Cirrhosis (yes/no)

1.28 (0.85–1.91)

0.234

Child–Pugh class (A/B)

1.88 (1.42–2.50)

 < 0.001

1.59 (1.11–2.29)

0.012

Fractional ablation (yes/no)

1.53 (1.08–2.17)

0.018

1.09 (0.73–1.64)

0.668

Ablative.modality (RFA/MWA/AHC)

1.08 (0.92–1.27)

0.359

Tumor number (single/multiple)

1.54 (1.17–2.02)

0.002

1.48 (1.10–2.00)

0.011

Tumor size (≤ 30 mm/ > 30 mm)

1.38 (1.04–1.83)

0.026

1.19 (0.85–1.66)

0.307

Alanine aminotransferase (U/L)

1.00 (1.00–1.01)

0.230

Aspartate aminotransferase (U/L)

1.01 (1.00–1.01)

0.007

1.01 (1.00–1.01)

0.146

Total bilirubin (μmol/L)

1.02 (1.01–1.03)

0.004

0.99 (0.98–1.01)

0.330

Albumin (g/l)

0.93 (0.90–0.96)

 < 0.001

0.98 (0.95–1.03)

0.440

INR

6.97 (2.62–18.54)

 < 0.001

3.33 (0.80–13.92)

0.100

Alpha fetoprotein (< 7/7–400/ > 400 ng/mL)

1.09 (0.88–1.350

0.407

Viral load (< 1000/1000–20,000/ > 20000 IU/mL)

1.23 (1.05–1.44)

0.012

1.10 (0.92–1.33)

0.295

NLR

1.02 (0.98–1.06)

0.411

PLR

1.00 (1.00–1.00)

0.130

MLR

2.05 (1.21–3.45)

0.007

1.95 (1.07–3.57)

0.029