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Table 2 Symptoms and management of long-term complications

From: Consensus care recommendations for alfapump® in cirrhotic patients with refractory or recurrent ascites

Clinical symptom

Diagnosis/complication

Management

Distended abdomen

Ascites accumulation

(Device malfunction)

Paracentesis

Referral to expert centre

Determination of type of device malfunction

Surgical re-intervention if indicated

Elevated protein in urine

Ascites in urine

(consequence of alfapump® action)

No reason for concern if no other signs of UTI are present

Fever (≥ 2 days)

Infection

· SBP

· Device colonisation

· UTI

Initiation of antibiotic treatment

Referral to expert centre

Diagnostic paracentesis for exclusion of SBP

Identification of causative agent incl. antibiotic susceptibility profile in collaboration with local infection management

Explant pump if no signs of improvement after initiation of antibiotic treatment

Implant site redness, swelling, or pain

Cellulitis

Ascites leakage into pump pocket

Initiate antibiotic treatment

Revision of device (catheter dislocation?)

Surgical re-intervention if indicated

Increase of serum creatinine ≥ 0.3 mg/dl or 1.5–twofold above pre-implant levels

AKI

Treatment with albumin infusion with or without terlipressin according to guidelines and local standards

(Temporary) reduction of TDV

Urination problems

Dehydration

AKI

Revision of fluid management

(Temporary) reduction of TDV

Treatment with antibiotics, terlipressin and albumin infusion according to guidelines and local standards

Wound leakage

Wound dehiscence

Catheter dislocation (ascites leakage into pump pocket)

Wound revision

Surgical re-intervention if indicated