|
Parameter
|
Univariate analysis, HR (95% CI)
|
P
|
Mutivariate analysis, HR (95% CI)
|
P
|
|---|
|
Gender
|
|
Male
|
1 (Referent)
|
0.384
|
–
|
–
|
|
Femal
|
0.728 (0.357–1.488)
|
–
|
–
|
–
|
|
Age
|
| ≦60 yr |
1 (Referent)
|
0.929
|
–
|
–
|
|
>60 yr
|
0.970 (0.499–1.887)
|
–
|
–
|
–
|
|
T stage
|
|
T2-3
|
1 (Referent)
|
0.007
|
–
|
–
|
|
T4
|
3.346 (1.388–8.065)
|
–
|
–
|
–
|
|
N stage
|
|
N0
|
1 (Referent)
|
< 0.001
|
–
|
–
|
|
N1
|
1.312 (0.508–3.384)
|
–
|
–
|
–
|
|
N2
|
5.290 (2.464–11.355)
|
–
|
–
|
–
|
|
TNM stage
|
|
II
|
1 (Referent)
|
0.005
|
1 (Referent)
|
0.003
|
|
III
|
2.789 (1.365–5.700)
|
–
|
3.010 (1.470–6.163)
| |
|
Vascular invasion
|
|
Absent
|
1 (Referent)
|
0.085
|
–
|
–
|
|
Present
|
2.006 (1.015–3.964)
|
–
|
–
|
–
|
|
Location
|
|
Right Colon
|
1 (Referent)
|
0.090
|
–
|
–
|
|
Left Colon
|
0.345 (0.128–0.933)
| | | |
|
Rectum
|
0.858 (0.405–1.817)
|
–
|
–
|
–
|
|
Microsatellite
|
|
pMMR
|
1 (Referent)
|
0.118
|
–
|
–
|
|
dMMR
|
2.129 (0.825–5.494)
|
–
|
–
|
–
|
|
mSEPT9
|
|
Negative
|
1 (Referent)
|
0.020
|
1 (Referent)
|
0.009
|
|
Positive
|
2.509 (1.175–5.359)
|
–
|
2.741 (1.281–5.865)
|
–
|
- pMMR: proficient mismatch repair; dMMR: different mismatch
repair;
- mSEPT9: methylated septin 9 gene; CRC: colorectal cancer
