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Table 2 Univariate and multivariate analysis of disease free survival in CRC patients with stage II-III

From: Methylated septin 9 gene is an important prognostic marker in stage II and stage III colorectal cancer for evaluating local recurrence or distant metastasis after surgery

Parameter Univariate analysis, HR (95% CI) P Mutivariate analysis, HR (95% CI) P
Gender
 Male 1 (Referent) 0.384
 Femal 0.728 (0.357–1.488)
Age
60 yr 1 (Referent) 0.929
 >60 yr 0.970 (0.499–1.887)
T stage
 T2-3 1 (Referent) 0.007
 T4 3.346 (1.388–8.065)
N stage
 N0 1 (Referent)  < 0.001
 N1 1.312 (0.508–3.384)
 N2 5.290 (2.464–11.355)
TNM stage
 II 1 (Referent) 0.005 1 (Referent) 0.003
 III 2.789 (1.365–5.700) 3.010 (1.470–6.163)  
Vascular invasion
 Absent 1 (Referent) 0.085
 Present 2.006 (1.015–3.964)
Location
 Right Colon 1 (Referent) 0.090
 Left Colon 0.345 (0.128–0.933)    
 Rectum 0.858 (0.405–1.817)
Microsatellite
 pMMR 1 (Referent) 0.118
 dMMR 2.129 (0.825–5.494)
mSEPT9
 Negative 1 (Referent) 0.020 1 (Referent) 0.009
 Positive 2.509 (1.175–5.359) 2.741 (1.281–5.865)
  1. pMMR: proficient mismatch repair; dMMR: different mismatch repair;
  2. mSEPT9: methylated septin 9 gene; CRC: colorectal cancer