Table 1 Correlations between serum methylated septin 9 gene and clinico-pathological features of colorectal cancer patients (n = 144) (Chi square and Fisher’s tests)
Parameter | Negative group (%) | Positive group (%) | P |
|---|---|---|---|
Gender | |||
Male | 31(36.0) | 55(64.0) | 0.121 |
Female | 29(50.0) | 29(50.0) | |
Age | |||
≦60 yr | 26(41.9) | 36(58.1) | 0.955 |
>60 yr | 34(41.5) | 48(58.5) | |
T stage | |||
T1 | 7(87.5) | 1(12.5) | < 0.001 |
T2 | 13(76.5) | 4(23.5) | |
T3 | 18(45.0) | 22(55.0) | |
T4 | 22(27.8) | 57(72.2) | |
N stage | |||
N0 | 38(46.3) | 44(53.7) | 0.116 |
N1 | 13(46.4) | 15(53.6) | |
N2 | 9(26.5) | 25(73.5) | |
Distant metastasis (M) | |||
M0 | 58(49.6) | 59(50.4) | < 0.001 |
M1 | 2(7.4) | 25(92.6) | |
TNM stage | |||
I | 19(82.6) | 4(17.4) | < 0.001 |
II | 19(38.8) | 30(61.2) | |
III | 20(44.4) | 25(55.6) | |
IV | 2(7.4) | 25(92.6) | |
Vascular invasion | |||
Absent | 51(47.7) | 56(52.3) | 0.020 |
Present | 9(24.3) | 28(75.7) | |
Histologic grade | |||
Low level | 1(7.1) | 13(92.9) | 0.006 |
Medium level | 57(44.9) | 70(55.1) | |
High level | 2(66.7) | 1(33.3) | |
Location | |||
Right Colon | 10(30.3) | 23(69.7) | 0.064 |
Left Colon | 16(34.8) | 30(65.2) | |
Rectum | 34(52.3) | 31(47.7) | |
Microsatellite | |||
pMMR | 59(45.0) | 72(55.0) | 0.008 |
dMMR | 1(7.7) | 12(92.3) | |