Skip to main content

Table 1 Characteristics of patients with submucosal oesophageal squamous cells

From: Submucosal oesophageal squamous cell carcinoma with lymph node metastasis: a case report and literature review

No

Age/sex

Clinical presentation

Upper gastrointestinal endoscopy

Endoscopic ultrasound

Size (cm)

metastasis

Pathology

Treatment

Follow-up outcome

1

65/male

Dysphagia, weight loss

Concentric narrowing of the oesophagus

–

4–5

None

Cancer cells originated from squamous epithelial cysts in the oesophageal wall

Chemoradiotherapy

7 weeks Patient died

2

58/male

Dysphagia

 

No unequivocal findings

3

Resection margin positive

Poorly differentiated squamous cell carcinoma, infiltrating all layers of the oesophageal wall

Surgery + radiochemotherapy

13 months in fine general condition

3

58/male

Dysphagia, weight loss

–

–

7 × 5 × 5

None

Squamous epithelial malignancy lacking glandular formation

Surgery

6 months in fine general condition

4

45/female

Dysphagia, weight loss

Smooth stricture with normal overlying mucosa

Heteroechoic mass lesion in submucosa

3.3 × 2.5

Bone

Squamous cell carcinoma beneath t normal epithelium

Palliative chemoradiotherapy

2 months

No change in the size of the tumour

5

60/male

Dysphagia

Small mass in the oesophagus and a large submucosal mass in the gastric cardia

–

–

Gastric

Oesophageal squamous cell carcinoma with submucosal growth pattern

Surgery

110 days

Patient died

6

63/male

Abdominal distension

Mucosal eminence with normal overlying mucosa

Heterogeneous and hypoechoic in muscularis mucosa or submucosa

1.3 × 1.0 × 0.3

Vertical margin positive

Under normal epithelium, atypical cells with an increased nuclear-to-cytoplasmic ratio could be seen

ESD + radiotherapy

2 years

No recurrence or metastasis

7

65/male

Dysphagia

Hemispherical lesion with smooth mucosa

Hypoechoic and heterogeneous echotexture in the submucosa

1.5 × 1.5 × 1.0

None

Atypical squamous cell clusters could be seen under normal epithelium

ESD

1 year

No recurrence and metastasis