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Table 2 Recurrence rate according to the grade of venous invasion

From: Risk stratification for predicting postoperative recurrence/metastasis of colorectal cancer by grade of venous invasion coupled with histological subtype

 

Grade of venous invasion

Total

 

v0

v1

v2

v3

WMDA

     

 *Recurrence (%)

8/68 (11.8%)

9/57 (15.8%)

17/23 (73.9%)

3/4 (75.0%)

37/152 (24.3%)

  RR (95% CI)

Reference

1.342 (0.565–3.200)

6.283 (3.364–10.834)

6.375 (2.209–9.023)

 

  **p value

 

0.604

 < 0.001

0.010

 

 Median DTR (range)

438.5 (268–1264)

593 (105–2212)

232 (18–2561)

300 (51–368)

374 (18–2561)

PDA

     

 Recurrence (%)

5/18 (27.8%)

17/52 (32.7%)

6/18 (33.3%)

6/10 (60.0%)

34/98 (34.7%)

  RR (95% CI)

Reference

1.177 (0.555–2.839)

1.200 (0.455–3.217)

2.160 (0.874–4.695)

 

  p value

 

0.776

1.000

0.125

 

 Median DTR (range)

608 (195–3407)

341 (123–1070)

207.5 (139–539)

142.5 (87–297)

244 (87–3407)

MUA

     

 Recurrence (%)

5/33 (15.2%)

8/26 (30.8%)

2/5 (40.0%)

 

15/64 (23.4%)

  RR (95% CI)

Reference

2.031 (0.781–5.423)

2.640 (0.645–7.310)

  

  p value

 

0.209

0.223

  

 Median DTR (range)

547 (423–1600)

582.5 (22–993)

633.5 (282–985)

 

572 (22–1600)

SRCC

     

 Recurrence (%)

0/1 (0.0%)

2/6 (33.3%)

0/1 (0.0%)

1/1 (100.0%)

3/9 (33.3%)

  RR (95% CI)

Reference

N.A

N.A

N.A

 

  p value

     

 Median DTR (range)

 

785.5 (436–1135)

 

2710 (2710–2710)

1135 (436–2710)

  1. WMDA well-to-moderately differentiated adenocarcinoma, PDA poorly differentiated adenocarcinoma, MUA mucinous adenocarcinoma, SRCC signet-ring cell carcinoma, RR relative risk, CI confidence interval, DTR days to recurrence, N.A not applicable, v0 no venous invasion, v1 1–3 invasions/glass slide, v2 4–6 invasions/glass slide, v3 ≥ 7 invasions/glass slide
  2. The filling type of venous invasion in a macroscopically identifiable vein with a minor axis of ≥ 1 mm raised the grade of a v1 or v2 by 1
  3. *In this study cohort, there were no cases of local recurrence throughout the histological subtypes. Therefore, recurrence means distant metastasis due to hematogenous/lymphatic spread or peritoneal dissemination
  4. **Statistical analysis was performed by Fisher's exact test