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Table4 Prognostic factors for overall survival of patient with SCRC

From: Clinicopathologic characteristics and prognosis of synchronous colorectal cancer: a retrospective study

Characteristics Univariate analysis Multivariate analysis
HR (95%CI) P valuea HR (95%CI) P valuea
Sex
 Female 1 (Reference)   
 Male 1.30 (0.79–2.12) 0.305   
EOCRC or LOCRC
 LOCRC 1 (Reference) 1 (Reference)
 EOCRC 0.55 (0.28–1.11) 0.096 0.28 (0.13–0.62) 0.002
Family history of tumours
 No 1 (Reference) 1 (Reference)
 Yes 0.37 (0.09–1.49) 0.160 0.57 (0.12–2.80) 0.488
BMI (kg/m2)
 18.5 to 24 1 (Reference)   
 < 18.5 0.97 (0.52–1.83) 0.927   
 ≥ 24 0.78 (0.47–1.28) 0.320   
Haemoglobin (g/L)
 > 110 1 (Reference) 1 (Reference)
 ≤ 100 1.80 (1.17–2.77) 0.007 1.75 (1.07–2.84) 0.025
Platelet counts (109/L)
 ≤ 300 1 (Reference)   
 > 300 1.20 (0.76–1.89) 0.431   
WBC (109/L)
 ≤ 10 1 (Reference)   
 > 10 1.19 (0.60–2.38) 0.622   
CEA (ng/mL)
 ≤ 10 1 (Reference) 1 (Reference)
 > 10 2.65 (1.72–4.09) < 0.001 1.38 (0.82–2.31) 0.220
CA199 (kU/L)
 ≤ 27 1 (Reference) 1 (Reference)
 > 27 2.24 (1.44–3.47) < 0.001 1.04 (0.61–1.78) 0.884
CA125 (kU/L)
 ≤ 35 1 (Reference) 1 (Reference)
 > 35 5.88 (3.49–9.91) < 0.001 4.19 (2.23–7.85) < 0.001
CA153 (kU/L)
 ≤ 25 1 (Reference) 1 (Reference)
 > 25 5.78 (1.79–18.69) 0.003 3.65 (0.98–13.57) 0.054
AFP (ng/mL)
 ≤ 7 1 (Reference)   
 > 7 0.68 (0.22–2.16) 0.516   
Type of ascites
 No 1 (Reference) 1 (Reference)
 Serous 1.28 (0.62–2.66) 0.505 0.55 (0.24–1.24) 0.150
 Bloody 6.78 (2.12–21.74) 0.001 3.53 (0.87–14.27) 0.077
Tumor location
 Right colon 1 (Reference)   
 Left colon 0.68 (0.35–1.32) 0.257   
 Rectum 0.77 (0.42–1.41) 0.398   
 Multiple segment 0.68 (0.38–1.23) 0.200   
Radical or palliative surgery
 Radical 1 (Reference) 1 (Reference)
 Palliative 6.45 (4.17–9.96) < 0.001 2.87 (1.17–7.02) 0.021
 (y)pTNM staging
 0–I 1 (Reference) 1 (Reference)
 II 3.13 (0.72–13.6) 0.129 2.77 (0.63–12.22) 0.178
 III 5.32 (1.26–22.53) 0.023 5.34 (1.24–22.98) 0.025
 IV 17.27 (4.18–71.47) < 0.001 5.89 (1.16–29.77) 0.032
Number of retrieved lymph nodes
 < 12 1 (Reference) 1 (Reference)
 ≥ 12 1.82 (0.94–3.53) 0.075 1.55 (0.75–3.22) 0.240
Gross classification
 Mass type 1 (Reference)   
 Infiltration type 1.75 (0.53–5.71) 0.355   
 Ulceration type 0.86 (0.55–1.34) 0.499   
Histological type
 Classical adenocarcinoma 1 (Reference)   
 Mucinous adenocarcinoma 0.64 (0.26–1.57) 0.328   
 Signet ring cell carcinoma 0 (0-Inf) 0.994   
Differentiation grade
 Well differentiated 1 (Reference)   
 Moderately differentiated 1.15 (0.65–2.02) 0.634   
 Poorly differentiated 1.09 (0.53–2.23) 0.824   
Vessel invasion
 Negative 1 (Reference) 1 (Reference)
 Positive 1.82 (1.11–2.99) 0.018 1.09 (0.60–1.98) 0.780
Neural invasion
 Negative 1 (Reference) 1 (Reference)
 Positive 2.37 (1.45–3.87) 0.001 1.32 (0.71–2.44) 0.378
Ki67 expression
 Low 1 (Reference) 1 (Reference)
 Moderate 0.64 (0.28–1.43) 0.275 1.10 (0.45–2.66) 0.833
 High 0.58 (0.30–1.13) 0.111 1.00 (0.47–2.13) 0.999
MMR status
 pMMR 1 (Reference) 1 (Reference)
 dMMR 0.48 (0.22–1.04) 0.063 0.77 (0.32–1.83) 0.551
  1. HR hazard ratio, CI confidence interval. aThe bolded P value was statistically significant (P < 0.05)