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Table 2 Clinicopathological characteristics of patients with EOCRC

From: Clinicopathologic characteristics and prognosis of synchronous colorectal cancer: a retrospective study

  LO-PCRC EO-PCRC P valuea
(LO-PCRC vs. EO-PCRC)
LO-SCRC EO-SCRC P valuea
(LO-SCRC vs. EO-SCRC)
P valuea
(EO-PCRC vs. EO-SCRC)
N = 875 N = 257 N = 358 N = 64
Sex (%)
 Female 322 (36.80) 116 (45.14) 0.019 104 (29.05) 22 (34.38) 0.478 0.157
 Male 553 (63.20) 141 (54.86) 254 (70.95) 42 (65.62)
Family history of tumours (%)
 No 854 (97.60) 244 (94.94) 0.047 341 (95.25) 58 (90.62) 0.229 0.311
 Yes 21 (2.40) 13 (5.06) 17 (4.75) 6 (9.38)  
BMI (kg/m2) (%)
 18.5 to 24 539 (61.60) 136 (52.92) 0.041 213 (59.50) 39 (60.94) 0.639 0.257
 < 18.5 75 (8.57) 29 (11.28) 39 (10.89) 9 (14.06)
 ≥ 24 261 (29.83) 92 (35.80) 106 (29.61) 16 (25.00)
Hemoglobin (g/L) (%)
 > 110 630 (72.00) 174 (67.70) 0.209 223 (62.29) 36 (56.25) 0.439 0.115
 ≤ 100 245 (28.00) 83 (32.30) 135 (37.71) 28 (43.75)
Platelet counts (109/L) (%)
 ≤ 300 661 (75.54) 172 (66.93) 0.008 254 (70.95) 35 (54.69) 0.015 0.092
 > 300 214 (24.46) 85 (33.07) 104 (29.05) 29 (45.31)
WBC (109/L) (%)
 ≤ 10 817 (93.37) 236 (91.83) 0.475 330 (92.18) 58 (90.62) 0.864 0.953
 > 10 58 (6.63) 21 (8.17) 28 (7.82) 6 (9.38)
CEA (ng/mL) (%)
 ≤ 10 645 (73.71) 215 (83.66) 0.001 249 (69.55) 48 (75.00) 0.465 0.153
 > 10 230 (26.29) 42 (16.34) 109 (30.45) 16 (25.00)
CA199 (kU/L) (%)
 ≤ 27 701 (80.11) 204 (79.38) 0.864 278 (77.65) 42 (65.62) 0.056 0.031
 > 27 174 (19.89) 53 (20.62) 80 (22.35) 22 (34.38)
CA125 (kU/L) (%)
 ≤ 35 806 (92.11) 239 (93.00) 0.739 329 (91.90) 54 (84.38) 0.093 0.052
 > 35 69 (7.89) 18 (7.00) 29 (8.10) 10 (15.62)
CA153 (kU/L) (%)
 ≤ 25 860 (98.29) 251 (97.67) 0.700 354 (98.88) 61 (95.31) 0.126 0.550
 > 25 15 (1.71) 6 (2.33) 4 (1.12) 3 (4.69)
AFP (ng/mL) (%)
 ≤ 7 843 (96.34) 243 (94.55) 0.272 347 (96.93) 55 (85.94) 0.001 0.034
 > 7 32 (3.66) 14 (5.45) 11 (3.07) 9 (14.06)
Type of ascites (%)
 No 816 (93.26) 248 (96.50) 0.157 330 (92.18) 59 (92.19) 0.745 0.208
 Serous 52 (5.94) 8 (3.11) 25 (6.98) 5 (7.81)
 Bloody 7 (0.80) 1 (0.39) 3 (0.84) 0 (0.00)
Tumor location (%)
 Right colon 178 (20.34) 62 (24.12) 0.405 65 (18.16) 16 (25.00) 0.539 < 0.001
 Left colon 266 (30.40) 77 (29.96) 82 (22.91) 11 (17.19)
 Rectum 431 (49.26) 118 (45.91) 94 (26.26) 16 (25.00)
 Multiple segment 117 (32.68) 21 (32.81)
Radical or palliative surgery (%)
 Radical 771 (88.11) 237 (92.22) 0.082 310 (86.59) 51 (79.69) 0.210 0.007
 Palliative 104 (11.89) 20 (7.78) 48 (13.41) 13 (20.31)
 (y)pTNM staging (%)
 0–I 117 (13.37) 37 (14.40) 0.214 46 (12.85) 5 (7.81) 0.129 < 0.001
 II 336 (38.40) 106 (41.25) 110 (30.73) 20 (31.25)
 III 292 (33.37) 89 (34.63) 133 (37.15) 19 (29.69)
 IV 130 (14.86) 25 (9.73) 69 (19.27) 20 (31.25)
Number of retrieved lymph nodes (%)
 < 12 760 (86.86) 233 (90.66) 0.127 334 (93.30) 62 (96.88) 0.415 0.169
 ≥ 12 115 (13.14) 24 (9.34) 24 (6.70) 2 (3.12)
Gross classification (%)
 Mass type 324 (37.03) 91 (35.41) 0.763 141 (39.39) 27 (42.19) 0.395 0.064
 Infiltration type 6 (0.69) 1 (0.39) 4 (1.12) 2 (3.12)
 Ulceration type 545 (62.29) 165 (64.20) 213 (59.50) 35 (54.69)
Histological type (%)
 Classical adenocarcinoma 829 (94.74) 232 (90.27) 0.001 333 (93.02) 58 (90.62) 0.583 0.675
 Mucinous adenocarcinoma 46 (5.26) 22 (8.56) 23 (6.42) 6 (9.38)
 Signet ring cell carcinoma 0 (0.00) 3 (1.17) 2 (0.56) 0 (0.00)
Differentiation grade (%)
 Well differentiated 129 (14.74) 42 (16.34) 0.163 46 (12.85) 13 (20.31) 0.143 0.557
 Moderately differentiated 632 (72.23) 171 (66.54) 255 (71.23) 38 (59.38)
 Poorly differentiated 114 (13.03) 44 (17.12) 57 (15.92) 13 (20.31)
Vessel invasion (%)
 Negative 735 (84.00) 220 (85.60) 0.600 287 (80.17) 52 (81.25) 0.976 0.502
 Positive 140 (16.00) 37 (14.40) 71 (19.83) 12 (18.75)
Neural invasion (%)
 Negative 695 (79.43) 209 (81.32) 0.564 289 (80.73) 50 (78.12) 0.755 0.687
 Positive 180 (20.57) 48 (18.68) 69 (19.27) 14 (21.88)
Ki67 expression (%)
 Low 48 (5.49) 19 (7.39) 0.469 23 (6.42) 5 (7.81) 0.680 0.982
 Moderate 114 (13.03) 30 (11.67) 53 (14.80) 7 (10.94)
 High 713 (81.49) 208 (80.93) 282 (78.77) 52 (81.25)
MMR status (%)
 pMMR 837 (95.66) 217 (84.44) < 0.001 321 (89.66) 49 (76.56) 0.006 0.190
 dMMR 38 (4.34) 40 (15.56) 37 (10.34) 15 (23.44)
Alive status (%)
 Alive 718 (82.06) 237 (92.22) < 0.001 283 (79.05) 55 (85.94) 0.271 0.185
 Death 157 (17.94) 20 (7.78) 75 (20.95) 9 (14.06)
  1. aThe bolded P value was statistically significant (P < 0.05)