Table 5 Joint effects analysis of CDK1 and CDK4 expression in HCC patients
Group | CDK1 | CDK4 | Patient | OS | |||||
|---|---|---|---|---|---|---|---|---|---|
No. of events | MST | HR (95% CI) | P | Adjusted HRa (95% CI) | Adjusted Pa | ||||
TCGA |  |  | (n = 370) |  | days |  |  |  |  |
 A | High | High | 135 | 56 | 899 | 1 |  | 1 |  |
 B | High | Low | 50 | 21 | 1490 | 0.769 (0.465–1.271) | 0.305 | 0.704 (0.408–1.216) | 0.209 |
 C | Low | High | 50 | 20 | 1622 | 0.760 (0.455–1.269) | 0.294 | 0.857 (0.489–1.502) | 0.591 |
 D | Low | Low | 135 | 33 | 2456 | 0.430 (0.279–0.662) |  < 0.001 | 0.491 (0.307–0.785) | 0.003 |
GSE14520 |  |  | (n = 212) |  | months |  |  |  |  |
 a | High | High | 80 | 37 | 57.9 | 1 |  | 1 |  |
 b | High | Low | 2 | 12 | 52.7 | 0.989 (0.515–1.897) | 0.972 | 1.170 (0.606–2.258) | 0.641 |
 c | Low | High | 26 | 10 | NA | 0.756 (0.376–1.522) | 0.434 | 0.566 (0.273–1.173) | 0.126 |
 d | Low | Low | 80 | 23 | NA | 0.480 (0.285–0.808) | 0.006 | 0.431 (0.255–0.729) | 0.002 |