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Table 4 Relationship between CDK gene expression and HCC prognosis in GSE14520 cohort

From: Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma

Expression

Patient (n = 212)

OS

No. of events

MST (months)

HR (95% CI)

P

Adjusted HR a (95% CI)

Adjusted Pa

CDK1

       

 Low

106

33

NA

1

 

1

 

 High

106

49

54.8

1.848 (1.187–2.876)

0.07

2.237 (1.424–3.514)

 < 0.001

CDK3

       

 Low

106

43

NA

1

 

1

 

 High

106

39

NA

0.902 (0.585–1.392)

0.642

1.116 (0.716–1.742)

0.628

CDK4

       

 Low

106

35

NA

1

 

1

 

 High

106

47

NA

1.605 (1.036–2.487)

 

1.579 (1.013–2.461)

0.044

CDK6

       

 Low

106

44

NA

1

 

1

 

 High

106

38

NA

0.812 (0.526–1.254)

0.348

0.88 (0.567–1.365)

0.568

  1. HBV, hepatitis B virus; MST, median survival time; OS, overall survival; HR, hazard ratio; CI, confidence interval; NA, not available
  2. aAdjusted for tumor size, cirrhosis, BCLC stage