Variables | Patient (n = 370) | OS | |||
---|---|---|---|---|---|
No. of events | MST (days) | HR (95% CI) | P | ||
Age (years) | Â | Â | Â | Â | Â |
 ≤ 60 | 177 | 55 | 2532 | 1 |  |
 > 60 | 193 | 75 | 1622 | 1.246 (0.879–1.766) | 0.217 |
Gender | Â | Â | Â | Â | Â |
 Female | 121 | 51 | 1490 | 1 |  |
 Male | 249 | 79 | 2486 | 0.817 (0.573–1.164) | 0.262 |
Race | Â | Â | Â | Â | Â |
 Asian | 157 | 44 | NA | 1 |  |
 White + other | 203 | 81 | 1386 | 1.309 (0.904–1.896) | 0.154 |
Alcohol consumptiona | Â | Â | Â | Â | Â |
 No | 234 | 84 | 1694 | 1 |  |
 Yes | 117 | 40 | 1624 | 1.026 (0.703–1.496) | 0.896 |
Ishak fibrosis scoreb | Â | Â | Â | Â | Â |
 0—No Fibrosis | 74 | 30 | 2131 | 1 |  |
 1,2—Portal Fibrosis | 31 | 9 | 1372 | 0.917 (0.429–1.962) | 0.823 |
 3,4—Fibrous Speta | 28 | 6 | NA | 0.682 (0.281–1.654) | 0.397 |
 5—Nodular Formation and Incomplete Cirrhosis | 9 | 2 | 1386 | 0.750 (0.177–3.167) | 0.695 |
 6—Established Cirrhosis | 69 | 17 | NA | 0.766 (0.418–1.403) | 0.388 |
TNM stagec | Â | Â | Â | Â | Â |
 I | 171 | 42 | 2532 | 1 |  |
 II | 85 | 26 | 1852 | 1.427 (0.874–2.330) | 0.155 |
 III or IV | 90 | 48 | 770 | 2.764 (1.823–4.190) |  < 0.001 |
Histologic Graded | Â | Â | Â | Â | Â |
 G1 | 55 | 18 | 2116 | 1 |  |
 G2 | 177 | 60 | 1685 | 1.181 (0.697–2.000) | 0.537 |
 G3 | 121 | 43 | 1622 | 1.233 (0.711–2.140) | 0.456 |
 G4 | 12 | 5 | NA | 1.693 (0.626–4.584) | 0.300 |
Serum AFPe | Â | Â | Â | Â | Â |
 ≤ 400 ng/ml | 213 | 62 | 2456 | 1 |  |
 > 400 ng/ml | 64 | 22 | 2486 | 1.055 (0.645–1.724) | 0.832 |
Radical resectionf | Â | Â | Â | Â | Â |
 R0 | 323 | 110 | 1852 | 1 |  |
 R1/R2/RX | 40 | 17 | 837 | 2.030 (1.213–3.395) | 0.007 |
Micro vascular invasiong | Â | Â | Â | Â | Â |
 No | 206 | 60 | 2131 | 1 |  |
 Yes | 108 | 36 | 2486 | 1.351 (0.892–2.047) | 0.155 |
Child–Pugh scoreh |  |  |  |  |  |
 A | 216 | 59 | 2542 | 1 |  |
 B/C | 22 | 9 | 1005 | 1.614 (0.796–3.270) | 0.184 |