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Table 1 Clinical data of 370 HCC patients from TCGA database

From: Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma

Variables

Patient (n = 370)

OS

No. of events

MST (days)

HR (95% CI)

P

Age (years)

     

 ≤ 60

177

55

2532

1

 

 > 60

193

75

1622

1.246 (0.879–1.766)

0.217

Gender

     

 Female

121

51

1490

1

 

 Male

249

79

2486

0.817 (0.573–1.164)

0.262

Race

     

 Asian

157

44

NA

1

 

 White + other

203

81

1386

1.309 (0.904–1.896)

0.154

Alcohol consumptiona

     

 No

234

84

1694

1

 

 Yes

117

40

1624

1.026 (0.703–1.496)

0.896

Ishak fibrosis scoreb

     

 0—No Fibrosis

74

30

2131

1

 

 1,2—Portal Fibrosis

31

9

1372

0.917 (0.429–1.962)

0.823

 3,4—Fibrous Speta

28

6

NA

0.682 (0.281–1.654)

0.397

 5—Nodular Formation and Incomplete Cirrhosis

9

2

1386

0.750 (0.177–3.167)

0.695

 6—Established Cirrhosis

69

17

NA

0.766 (0.418–1.403)

0.388

TNM stagec

     

 I

171

42

2532

1

 

 II

85

26

1852

1.427 (0.874–2.330)

0.155

 III or IV

90

48

770

2.764 (1.823–4.190)

 < 0.001

Histologic Graded

     

 G1

55

18

2116

1

 

 G2

177

60

1685

1.181 (0.697–2.000)

0.537

 G3

121

43

1622

1.233 (0.711–2.140)

0.456

 G4

12

5

NA

1.693 (0.626–4.584)

0.300

Serum AFPe

     

 ≤ 400 ng/ml

213

62

2456

1

 

 > 400 ng/ml

64

22

2486

1.055 (0.645–1.724)

0.832

Radical resectionf

     

 R0

323

110

1852

1

 

 R1/R2/RX

40

17

837

2.030 (1.213–3.395)

0.007

Micro vascular invasiong

     

 No

206

60

2131

1

 

 Yes

108

36

2486

1.351 (0.892–2.047)

0.155

Child–Pugh scoreh

     

 A

216

59

2542

1

 

 B/C

22

9

1005

1.614 (0.796–3.270)

0.184

  1. OS, overall survival; MST, median survival time; HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; NA, not available
  2. aAlcohol consumption information is not available for 19 patients
  3. bIshak fibrosis score information is not available for 159 patients
  4. cumor stage information is not available for 24 patients
  5. dHistologic grade information is not available for 5 patients
  6. eSerum AFP information is not available for 93 patients
  7. fRadical resection information is not available for 7 patients
  8. gMicro vascular invasion information is not available for 56 patients
  9. hChild-Pugh score information is not available for 132 patients