Table 1 Timeline table summary of the patient’s clinical course from December 2010 to May 2018 listing the main interventions and outcomes
Dates | Intervention | Outcome |
|---|---|---|
December 2010 | EGDS due to epigastric pain and persistent unproductive cough | A malignant lesion of the gastric antrum was discovered |
February 2011 | Subtotal gastrectomy and gastrojejunostomy | Clear cell gastric adenocarcinoma, R0 resection, stage IIb (pT4aN0M0) |
March 2011–July 2011 | Postoperative chemoradiotherapy | – |
August 2012 | Follow-up imaging | PD (two liver metastases) |
October 2012–March 2013 | First-line systemic therapy | PR |
February 2014 | Follow-up imaging | PD (enlargement of liver metastases) |
March–May 2014 | Second-line systemic therapy | Stopped after 3 cycles due to side effects |
May 2014 | Follow up imaging | SD, right hepatectomy suggested, but not feasible due to insufficient FLR (25%) |
July–August 2014 | TACE, PVE | SD, sufficient FLR achieved (41%) |
October 2014 | Right hepatectomy | R0 resection |
January 2015 | Follow up imaging | PD (two new liver metastases) |
January–May 2015 | Third-line systemic therapy | PD (enlargement of one of the liver metastases) |
July 2015 | SIRT | CR in target lesion |
December 2015 | Follow up imaging | PD (three new liver metastases) |
December 2015 | SIRT | CR |
June 2016 | Follow up imaging | PD (enlargement of liver metastases) |
July 2016 | SIRT | PR |
December 2016 | Follow up imaging | PD (enlargement of liver metastases) |
February 2017 | TACE | CR in target lesions |
March–November 2017 | Fourth-line systemic therapy | Disease progression (new liver metastases, ascites, and pleural effusions) |
December 2017–May 2018 | Hospice care | Death |