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Table 5 The relationship between H.pylori infection and liver function, renal function, carbohydrate metabolism, lipid metabolism in nonalcoholic fatty liver patients

From: Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China

Ā 

NAFLD (23,295)

Mild-NAFLD (18,260)

Moderate-NAFLD (4896)

Severe-NAFLD (139)

Parameter (n, %)

H.pyloriāˆ’ (14,678)

H.pylori+ (8617)

P value

H.pyloriāˆ’ (11,549)

H.pylori+ (6711)

P value

H.pyloriāˆ’ (3044)

H.pylori+ (1852)

P value

H.pyloriāˆ’ (85)

H.pylori+ (54)

P value

Liver function

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Ā AST increased

893 (6.2%)

529 (6.2%)

0.911

467 (4.1%)

261 (3.9%)

0.582

382 (12.7%)

217 (11.9%)

0.393

20 (24.7%)

11 (21.6%)

0.833

Ā ALT increased

4492 (30.7%)

2572 (29.9%)

0.237

2796 (24.3%)

1456 (21.8%)

ā€‰<ā€‰0.001

1643 (54.2%)

976 (52.9%)

0.391

53 (63.1%)

40 (75.5%)

0.139

Ā GGT increased

3580 (24.8%)

2123 (25.0%)

0.776

2456 (21.6%)

1382 (20.9%)

0.242

1093 (36.5%)

677 (37.0%)

0.712

31 (38.3%)

17 (33.3%)

0.584

Renal function

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Ā Scr increased

53 (0.4%)

25 (0.3%)

0.411

39 (0.3%)

22 (0.3%)

0.995

14 (0.5%)

3 (0.2%)

0.130

0

0

-

Ā BUN increased

824 (5.6%)

550 (6.4%)

0.014

670 (5.8%)

415 (6.2%)

0.299

149 (4.9%)

104 (5.6%)

0.287

5 (6.0%)

4 (7.4%)

0.737

Carbohydrate metabolism

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Ā FBG increased

1097 (8.5%)

810 (10.6%)

ā€‰<ā€‰0.001

727 (7.1%)

532 (9.0%)

ā€‰<ā€‰0.001

361 (13.4%)

262 (15.8%)

0.033

9 (11.1%)

4 (7.7)

0.568

Ā HbA1C increased

1286 (10.7%)

930 (12.8%)

ā€‰<ā€‰0.001

880 (9.3%)

611 (10.8%)

0.003

395 (16.0%)

311 (19.9%)

0.002

11 (18.3%)

8 (22.22%)

0.792

Lipid metabolism

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Ā Total cholesterol increased

1533 (10.5%)

918 (10.7%)

0.627

1149 (10.0%)

679 (10.1%)

0.721

375 (12.3%)

230 (12.4%)

0.929

9 (10.7%)

9 (16.7%)

0.315

Ā LDL-C increased

1114 (7.6%)

706 (8.2%)

0.100

849 (7.4%)

540 (8.1%)

0.087

259 (8.5%)

163 (8.8%)

0.714

6 (7.1%)

3 (5.6%)

1.000

Ā HDL-C decreased

2177 (14.7%)

1291 (15.0%)

0.746

1500 (13.0%)

873 (13.0%)

0.964

652 (21.4%)

398 (21.5%)

0.943

25 (29.8%)

20 (37.0%)

0.457

Ā Triglycerides increased

4953 (33.8%)

3049 (35.4%)

0.012

3433 (29.8%)

2118 (31.6%)

0.010

1484 (48.8%)

902 (48.8%)

0.976

36 (42.9%)

29 (53.7%)

0.226

  1. H. pylori, Helicobacter pylori; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; Scr, serum creatinine; BUN, blood urea nitrogen; NAFLD, nonalcoholic fatty liver disease
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BMC Gastroenterology

ISSN: 1471-230X

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