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Table 5 The relationship between H.pylori infection and liver function, renal function, carbohydrate metabolism, lipid metabolism in nonalcoholic fatty liver patients

From: Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China

  NAFLD (23,295) Mild-NAFLD (18,260) Moderate-NAFLD (4896) Severe-NAFLD (139)
Parameter (n, %) H.pylori− (14,678) H.pylori+ (8617) P value H.pylori− (11,549) H.pylori+ (6711) P value H.pylori− (3044) H.pylori+ (1852) P value H.pylori− (85) H.pylori+ (54) P value
Liver function             
 AST increased 893 (6.2%) 529 (6.2%) 0.911 467 (4.1%) 261 (3.9%) 0.582 382 (12.7%) 217 (11.9%) 0.393 20 (24.7%) 11 (21.6%) 0.833
 ALT increased 4492 (30.7%) 2572 (29.9%) 0.237 2796 (24.3%) 1456 (21.8%)  < 0.001 1643 (54.2%) 976 (52.9%) 0.391 53 (63.1%) 40 (75.5%) 0.139
 GGT increased 3580 (24.8%) 2123 (25.0%) 0.776 2456 (21.6%) 1382 (20.9%) 0.242 1093 (36.5%) 677 (37.0%) 0.712 31 (38.3%) 17 (33.3%) 0.584
Renal function             
 Scr increased 53 (0.4%) 25 (0.3%) 0.411 39 (0.3%) 22 (0.3%) 0.995 14 (0.5%) 3 (0.2%) 0.130 0 0 -
 BUN increased 824 (5.6%) 550 (6.4%) 0.014 670 (5.8%) 415 (6.2%) 0.299 149 (4.9%) 104 (5.6%) 0.287 5 (6.0%) 4 (7.4%) 0.737
Carbohydrate metabolism             
 FBG increased 1097 (8.5%) 810 (10.6%)  < 0.001 727 (7.1%) 532 (9.0%)  < 0.001 361 (13.4%) 262 (15.8%) 0.033 9 (11.1%) 4 (7.7) 0.568
 HbA1C increased 1286 (10.7%) 930 (12.8%)  < 0.001 880 (9.3%) 611 (10.8%) 0.003 395 (16.0%) 311 (19.9%) 0.002 11 (18.3%) 8 (22.22%) 0.792
Lipid metabolism             
 Total cholesterol increased 1533 (10.5%) 918 (10.7%) 0.627 1149 (10.0%) 679 (10.1%) 0.721 375 (12.3%) 230 (12.4%) 0.929 9 (10.7%) 9 (16.7%) 0.315
 LDL-C increased 1114 (7.6%) 706 (8.2%) 0.100 849 (7.4%) 540 (8.1%) 0.087 259 (8.5%) 163 (8.8%) 0.714 6 (7.1%) 3 (5.6%) 1.000
 HDL-C decreased 2177 (14.7%) 1291 (15.0%) 0.746 1500 (13.0%) 873 (13.0%) 0.964 652 (21.4%) 398 (21.5%) 0.943 25 (29.8%) 20 (37.0%) 0.457
 Triglycerides increased 4953 (33.8%) 3049 (35.4%) 0.012 3433 (29.8%) 2118 (31.6%) 0.010 1484 (48.8%) 902 (48.8%) 0.976 36 (42.9%) 29 (53.7%) 0.226
  1. H. pylori, Helicobacter pylori; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; Scr, serum creatinine; BUN, blood urea nitrogen; NAFLD, nonalcoholic fatty liver disease