|
Variables
|
Full sample (n = 71,633)
|
Matched sample (n = 29,974)
|
|---|
|
Univariate analysis
|
Multivariate analysis a
|
Univariate analysis
|
Multivariate analysis b
|
|---|
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
|---|
|
Age
|
1.02 (1.02–1.02)
|
< 0.001
|
1.02 (1.01–1.02)
|
< 0.001
|
1.01 (1.01–1.02)
|
< 0.001
|
1.01 (1.01–1.02)
|
< 0.001
|
|
Male sex (%)
|
3.13 (3.03–3.24)
|
< 0.001
|
1.09 (1.01–1.18)
|
0.022
|
0.35 (0.33–0.36)
|
< 0.001
|
0.98 (0.90–1.07)
|
0.601
|
|
BMI (kg/m2)
|
1.62 (1.61–1.63)
|
< 0.001
|
1.44 (1.42–1.45)
|
< 0.001
|
1.59 (1.57–1.61)
|
< 0.001
|
1.42 (1.40–1.44)
|
< 0.001
|
|
Systolic BP (mmHg)
|
1.03 (1.03–1.03)
|
< 0.001
|
1.00 (0.99–1.00)
|
< 0.001
|
1.03 (1.03–1.03)
|
< 0.001
|
1.00 (0.99–1.00)
|
0.003
|
|
Diastolic BP (mmHg)
|
1.07 (1.06–1.07)
|
< 0.001
|
1.02 (1.02–1.03)
|
< 0.001
|
1.06 (1.06–1.06)
|
< 0.001
|
1.02 (1.02–1.03)
|
< 0.001
|
|
FBG (mM)
|
1.46 (1.44–1.49)
|
< 0.001
|
1.03 (0.99–1.07)
|
0.087
|
1.43 (1.39–1.46)
|
< 0.001
|
1.05 (1.01–1.10)
|
0.018
|
|
HbA1C (%)
|
1.98 (1.92–2.04)
|
< 0.001
|
1.23 (1.15–1.30)
|
< 0.001
|
1.83 (1.76–1.90)
|
< 0.001
|
1.22 (1.13–1.30)
|
< 0.001
|
|
Total cholesterol (mM)
|
1.45 (1.42–1.47)
|
< 0.001
|
–
|
–
|
1.35 (1.31–1.39)
|
< 0.001
|
–
|
–c
|
|
LDL-C (mM)
|
1.57 (1.53–1.60)
|
< 0.001
|
1.35 (1.30–1.40)
|
< 0.001
|
1.44 (1.40–1.49)
|
< 0.001
|
1.34 (1.28–1.39)
|
< 0.001
|
|
HDL-C (mM)
|
0.07 (0.07–0.08)
|
< 0.001
|
0.36 (0.32–0.39)
|
< 0.001
|
0.09 (0.08–0.10)
|
< 0.001
|
0.37 (0.33–0.41)
|
< 0.001
|
|
Triglycerides (mM)
|
2.53 (2.47–2.58)
|
< 0.001
|
1.46 (1.42–1.50)
|
< 0.001
|
2.32 (2.25–2.39)
|
< 0.001
|
1.46 (1.41–1.50)
|
< 0.001
|
|
AST (IU/L)
|
1.05 (1.04–1.05)
|
< 0.001
|
0.97 (0.97–0.97)
|
< 0.001
|
1.04 (1.04–1.04)
|
< 0.001
|
0.97 (0.97–0.98)
|
< 0.001
|
|
ALT (IU/L)
|
1.05 (1.05–1.05)
|
< 0.001
|
1.03 (1.03–1.03)
|
< 0.001
|
1.04 (1.04–1.05)
|
< 0.001
|
1.03 (1.03–1.03)
|
< 0.001
|
|
GGT (IU/L)
|
1.03 (1.03–1.03)
|
< 0.001
|
1.00 (1.00–1.00)
|
< 0.001
|
1.02 (1.02–1.03)
|
< 0.001
|
1.00 (1.00–1.00)
|
< 0.001
|
|
Scr (μM)
|
1.02 (1.02–1.02)
|
< 0.001
|
0.99 (0.99–1.00)
|
< 0.001
|
1.02 (1.02–1.02)
|
< 0.001
|
1.00 (0.99–1.00)
|
< 0.001
|
|
BUN (mM)
|
1.11 (1.10–1.13)
|
< 0.001
|
0.99 (0.97–1.01)
|
0.275
|
1.10 (1.08–1.12)
|
< 0.001
|
0.99 (0.97–1.02)
|
0.546
|
|
H. pylori ( +)(%)
|
1.17 (1.14–1.21)
|
< 0.001
|
1.02 (0.97–1.08)
|
0.446
|
1.01 (0.96–1.06)
|
0.716
|
1.00 (0.94–1.06)
|
0.898
|
- aEstimated from Logistic regression analysis and adjusted for Age, sex, BMI, Systolic BP, Diastolic BP, FBG, HbA1C, LDL-C, HDL-C, Triglycerides, AST, ALT, GGT, Scr, BUN and H. pylori+ (%)
- bEstimated from Logistic regression analysis and adjusted for Age, sex, BMI, Systolic BP, Diastolic BP, FBG, HbA1C, LDL-C, HDL-C, Triglycerides, AST, ALT, GGT, Scr, BUN and H. pylori+ (%)
- cMulticollinearity analysis with the significant variables (variance inflation factor test, VIF) was conducted and Total cholesterol was excluded from the multivariate regression model (VIF = 12.104)
- H. pylori, Helicobacter pylori; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; Scr, serum creatinine; BUN, blood urea nitrogen; NAFLD, nonalcoholic fatty liver disease; OR, odd ratio; CI, confidence intervals
