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Table 2 The risk of NAFLD development in the univariate and multivariate analyses

From: Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China

Variables Full sample (n = 71,633) Matched sample (n = 29,974)
Univariate analysis Multivariate analysis a Univariate analysis Multivariate analysis b
OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Age 1.02 (1.02–1.02)  < 0.001 1.02 (1.01–1.02)  < 0.001 1.01 (1.01–1.02)  < 0.001 1.01 (1.01–1.02)  < 0.001
Male sex (%) 3.13 (3.03–3.24)  < 0.001 1.09 (1.01–1.18) 0.022 0.35 (0.33–0.36)  < 0.001 0.98 (0.90–1.07) 0.601
BMI (kg/m2) 1.62 (1.61–1.63)  < 0.001 1.44 (1.42–1.45)  < 0.001 1.59 (1.57–1.61)  < 0.001 1.42 (1.40–1.44)  < 0.001
Systolic BP (mmHg) 1.03 (1.03–1.03)  < 0.001 1.00 (0.99–1.00)  < 0.001 1.03 (1.03–1.03)  < 0.001 1.00 (0.99–1.00) 0.003
Diastolic BP (mmHg) 1.07 (1.06–1.07)  < 0.001 1.02 (1.02–1.03)  < 0.001 1.06 (1.06–1.06)  < 0.001 1.02 (1.02–1.03)  < 0.001
FBG (mM) 1.46 (1.44–1.49)  < 0.001 1.03 (0.99–1.07) 0.087 1.43 (1.39–1.46)  < 0.001 1.05 (1.01–1.10) 0.018
HbA1C (%) 1.98 (1.92–2.04)  < 0.001 1.23 (1.15–1.30)  < 0.001 1.83 (1.76–1.90)  < 0.001 1.22 (1.13–1.30)  < 0.001
Total cholesterol (mM) 1.45 (1.42–1.47)  < 0.001 1.35 (1.31–1.39)  < 0.001 c
LDL-C (mM) 1.57 (1.53–1.60)  < 0.001 1.35 (1.30–1.40)  < 0.001 1.44 (1.40–1.49)  < 0.001 1.34 (1.28–1.39)  < 0.001
HDL-C (mM) 0.07 (0.07–0.08)  < 0.001 0.36 (0.32–0.39)  < 0.001 0.09 (0.08–0.10)  < 0.001 0.37 (0.33–0.41)  < 0.001
Triglycerides (mM) 2.53 (2.47–2.58)  < 0.001 1.46 (1.42–1.50)  < 0.001 2.32 (2.25–2.39)  < 0.001 1.46 (1.41–1.50)  < 0.001
AST (IU/L) 1.05 (1.04–1.05)  < 0.001 0.97 (0.97–0.97)  < 0.001 1.04 (1.04–1.04)  < 0.001 0.97 (0.97–0.98)  < 0.001
ALT (IU/L) 1.05 (1.05–1.05)  < 0.001 1.03 (1.03–1.03)  < 0.001 1.04 (1.04–1.05)  < 0.001 1.03 (1.03–1.03)  < 0.001
GGT (IU/L) 1.03 (1.03–1.03)  < 0.001 1.00 (1.00–1.00)  < 0.001 1.02 (1.02–1.03)  < 0.001 1.00 (1.00–1.00)  < 0.001
Scr (μM) 1.02 (1.02–1.02)  < 0.001 0.99 (0.99–1.00)  < 0.001 1.02 (1.02–1.02)  < 0.001 1.00 (0.99–1.00)  < 0.001
BUN (mM) 1.11 (1.10–1.13)  < 0.001 0.99 (0.97–1.01) 0.275 1.10 (1.08–1.12)  < 0.001 0.99 (0.97–1.02) 0.546
H. pylori ( +)(%) 1.17 (1.14–1.21)  < 0.001 1.02 (0.97–1.08) 0.446 1.01 (0.96–1.06) 0.716 1.00 (0.94–1.06) 0.898
  1. aEstimated from Logistic regression analysis and adjusted for Age, sex, BMI, Systolic BP, Diastolic BP, FBG, HbA1C, LDL-C, HDL-C, Triglycerides, AST, ALT, GGT, Scr, BUN and H. pylori+ (%)
  2. bEstimated from Logistic regression analysis and adjusted for Age, sex, BMI, Systolic BP, Diastolic BP, FBG, HbA1C, LDL-C, HDL-C, Triglycerides, AST, ALT, GGT, Scr, BUN and H. pylori+ (%)
  3. cMulticollinearity analysis with the significant variables (variance inflation factor test, VIF) was conducted and Total cholesterol was excluded from the multivariate regression model (VIF = 12.104)
  4. H. pylori, Helicobacter pylori; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HbA1C, glycated hemoglobin; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; Scr, serum creatinine; BUN, blood urea nitrogen; NAFLD, nonalcoholic fatty liver disease; OR, odd ratio; CI, confidence intervals