Fig. 4

Visit schedule. S = screening, BL = baseline, V = visit, P = phone call. Screening procedures can take place in one visit or with MRI and DEXA apart, as preferred by site and patient. Patients are randomized to direct start (at BL) or delayed start (at V5). A phone cal (P) takes place one month after first leuprorelin injection. More extensive visits with MRI, questionnares and extensive lab take place at BL, 6, 18, 24 and 36 months. Extensive lab consists also of biobanking (samples stored at − 80 °C and shipping to core laboratory for measurement of female sex hormones in one run) and in case of ADPKD, 24 h urine collection. Between visits, site personnel will remind patients to administer the leuprorelin injections by phone or email