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Table 2 The differences of GD together with AIH

From: Graves’ disease overlapping with chronic hepatitis B and methimazole-induced liver injury and autoimmune hepatitis: a case report

Year

Authors

Clinical features

Diagnosis

Therapy

Effect

Ref. no

1999

Inoue K, et al

A 48-year F suffered from GD and AIH concurrently. A11 and DR4 are positive in HLA

GD-associated AIH

MMI

fT4 and ALT were decreased simultaneously after MMI use

[19]

2011

Sato et al

A 58-year F had three-year GD, and then PTU-induced AI-DILI

GD and PTU- induced AI-DILI

PSL

Elevated AST level decreased immediately by PSL

[22]

2019

Sano et al

A 15-year F suffered from GD and treated with MMI. She was ill with MMI-induced DILI with AIH futures

GD and MMI- induced-DILI with AIH futures

RIA, PSL

Elevated aminotransferases couldn’t be controlled after RIA but normalized after one-month PSL

[11]

2019

Sano et al

A 21-year F suffered from GD complicated with classical type II AIH

GD and type II AIH

RIA, PSL, LT

AIH couldn’t be controlled by RIA and PSL, and received LT

[11]

2019

Sano et al

A 39-year-F suffered from GD complicated with classical AIH

GD and AIH

PSL, RIA, LT

AIH couldn’t be controlled by PSL and RIA, and received LT

[11]

2019

Sawhney et al

A 24-year F was ill with classical type I AIH, and then GD was found

Type I AIH and GD

PSL, AZA, RIA

AIH be effectively controlled by the combination of PSL and AZA and RIA

[20]

  1. F female, GD graves’ disease, AIH autoimmune hepatitis, AI-DILI autoimmune-like drug-induced liver injury, MMI methimazole, PTU propylthiouracil, PSL prednisone, RIA radioactive iodine ablation, LT liver transplant, AZA azathioprine