Table 2 Baseline characteristics of ACLF patients
Variables | n = 124 | Non-survivors n = 61 | Survivors n = 63 | P value |
|---|---|---|---|---|
Age (yr) | 47.52 ± 11.88 | 49.21 ± 1.37 | 45.89 ± 1.62 | 0.121 |
Sex(M/F) | 103/21 | 51/10 | 52/11 | 0.874 |
ACLF etiology | ||||
Acute hepatic insult, n (%) | ||||
Alcoholic hepatitis | 16 (12.90%) | 8 (13.11%) | 8 (12.70%) | 0.888 |
HBV reactivation | 65 (52.42%) | 34 (55.74%) | 31 (49.21%) | 0.467 |
Bacterial infection | 34 (27.42%) | 17(27.87%) | 17 (26.98%) | 0.912 |
Others | 9 (7.26%) | 2 (3.28%) | 7 (11.11%) | 0.093 |
Underlying CLD, n (%) | ||||
CHB | 87 (70.16%) | 45 (73.77%) | 43 (68.25%) | 0.499 |
ALD | 21 (16.94%) | 8 (13.11%) | 13 (20.63%) | 0.264 |
NAFLD | 16 (12.90%) | 8 (13.11%) | 7 (11.11%) | 0.732 |
Clinic events at presentation, n (%) | ||||
Ascites | 124 (100%) | 61 (100%) | 63 (100%) | |
Jaundice | 124 (100%) | 61 (100%) | 63 (100%) | |
AKI | 30 (24.19%) | 20 (32.79%) | 9 (14.29%) | 0.015 |
HE | 43 (34.68%) | 31 (50.82%) | 12 (19.05%) | < 0.01 |
Acute variceal bleed | 17 (13.71%) | 9 (14.75%) | 8 (12.70%) | 0.739 |
SBP | 9 (7.3%) | 4 (6.56%) | 5 (7.94%) | 0.767 |
Parameter | ||||
PT (%) | 37.76 ± 14.54 | 36.69 ± 221 | 38.81 ± 1.44 | 0.421 |
Fb (g/L) | 1.56 ± 0.71 | 1.59 ± 0.11 | 1.54 ± 0.07 | 0.678 |
INR | 2.09 ± 0.69 | 2.37 ± 0.11 | 1.82 ± 0.05 | < 0.01 |
WBC(1 × 109/L) | 14.46 ± 8.47 | 7.60 ± 0.57 | 6.11 ± 0.35 | 0.027 |
PLT (1 × 109/L) | 99.90 ± 61.41 | 89.85 ± 6.44 | 109.6 ± 8.82 | 0.074 |
ALT (U/L) | 288.69 ± 396.73 | 230.5 ± 44.43 | 345.1 ± 55.16 | 0.109 |
GLU (mM) | 5.83 ± 3.32 | 6.15 ± 0.49 | 5.54 ± 0.36 | 0.316 |
TBIL (μM) | 320.62 ± 136.81 | 404.1 ± 16.06 | 239.8 ± 11.77 | < 0.01 |
CHOL (mM) | 2.58 ± 0.90 | 2.52 ± 0.11 | 2.65 ± 0.12 | 0.420 |
CREA (μM) | 66.09 ± 22.22 | 67.06 ± 2.89 | 65.17 ± 2.80 | 0.639 |
Organ failure | ||||
Kidney, n (%) | 11 (8.87%) | 6 (9.84%) | 5 (7.94%) | 0.710 |
Cerebral, n (%) | 20 (16.13%) | 15 (24.59%) | 5 (7.94%) | 0.012 |
Coagulation, n (%) | 43 (34.68%) | 33 (52.46%) | 10 (15.87%) | < 0.01 |
Circulation, n (%) | 15 (12.09%) | 8 (13.11%) | 7 (11.11%) | 0.732 |
Lung, n (%) | 34 (27.42%) | 22 (36.07%) | 12 (19.05%) | 0.034 |
Prognostic score | ||||
MELD | 25.16 ± 4.33 | 27.57 ± 0.51 | 22.83 ± 0.42 | < 0.01 |