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Table 1 Proteins related to cell growth and death, replication and repair, and cancers

From: MS275 as Class I HDAC inhibitor displayed therapeutic potential on malignant ascites by iTRAQ-based quantitative proteomic analysis

Pathway level

Pathway

Related proteins

Cell growth and death

Cell cycle

SFXN1;CCND3; SFXN2;

BUB1B;CDC20;EP300;CDK4;HIC2;RBX1;CCND1

Apoptosis

PARP1;LMNB1;LMNB2;TR10B;ENSA;ITPR3;AIFM1;CCD51;CATL1

Necroptosis

PARP1;H2AX;VDAC1;VDAC3;TR10B; AIFM1; STAT2; ADT4; ADT1; H2AY; VDAC2; PPID

Ferroptosis

STEA3;ACSL3;VDAC3;HMOX1;4F2;ACSL1; VDAC2; MBOA5

Cellular senescence

CCND3;VDAC1;Z36L3;VDAC3;ITPR3;ISC2A;HA1D;ADT4;ADT1;VDAC2;PPID;HUS1;CDK4;CCND1

p53 signaling pathway

STEA3;CCND3;TSP1; ZN346; CDK4;CCND1

Replication and repair

Nucleotide excision repair

DPOE4;RBX1

Base excision repair

PARP1;DPOE4

DNA replication

SFXN1;SFXN2; DPOE4

Homologous recombination

XLR

Cancers: Overview

Chemical carcinogenesis

GSTM6;GSTM7;PGH2;HYEP;MGST3;U2AFM

Viral carcinogenesis

ATF2;SCRIB;VDAC3;H2B2B;HA1D;LRRC1;CRLF1;VA0D1;CCND3;LRC58;H4;HDAC7;CDC20;EP300;CDK4;RANG;CCND1

MicroRNAs in cancer

DIK2A;VIME;PGH2;IF2B1;ENSA;TSP1;HMOX1;EP300;CCND1

Transcriptional misregulation in cancer

MLF1;PBX3;K319L;CEBPB;MITF;TNR16;Q9JLZ6

Proteoglycans in cancer

SDC4;ESPN;TSP1;ITPR3;ITB5;FINC;ITAV;;CATL1;|CD63;CCND1

Choline metabolism in cancer

DGKE;CTL2;CHKA

Central carbon metabolism in cancer

GTR1

Cancers: Specific types

Bladder cancer

TSP1;CDK4;CCND1

Pancreatic cancer

RALA;RALB;CDK4;CCND1

Renal cell carcinoma

GTR1;EP300;RBX1

Colorectal cancer

RALA;RALB;CCND1

Hepatocellular carcinoma

GSTM6;GSTM7;MGST3;HMOX1;CDK4;CCND1

Endometrial cancer

CCND1

Gastric cancer

CCND1

  1. MS275 treatment versus Ctrl, p < 0.05
  2. Upright letters = upregulated; inclined letters = downregulated