Skip to main content

Table 1 Proteins related to cell growth and death, replication and repair, and cancers

From: MS275 as Class I HDAC inhibitor displayed therapeutic potential on malignant ascites by iTRAQ-based quantitative proteomic analysis

Pathway level Pathway Related proteins
Cell growth and death Cell cycle SFXN1;CCND3; SFXN2;
BUB1B;CDC20;EP300;CDK4;HIC2;RBX1;CCND1
Apoptosis PARP1;LMNB1;LMNB2;TR10B;ENSA;ITPR3;AIFM1;CCD51;CATL1
Necroptosis PARP1;H2AX;VDAC1;VDAC3;TR10B; AIFM1; STAT2; ADT4; ADT1; H2AY; VDAC2; PPID
Ferroptosis STEA3;ACSL3;VDAC3;HMOX1;4F2;ACSL1; VDAC2; MBOA5
Cellular senescence CCND3;VDAC1;Z36L3;VDAC3;ITPR3;ISC2A;HA1D;ADT4;ADT1;VDAC2;PPID;HUS1;CDK4;CCND1
p53 signaling pathway STEA3;CCND3;TSP1; ZN346; CDK4;CCND1
Replication and repair Nucleotide excision repair DPOE4;RBX1
Base excision repair PARP1;DPOE4
DNA replication SFXN1;SFXN2; DPOE4
Homologous recombination XLR
Cancers: Overview Chemical carcinogenesis GSTM6;GSTM7;PGH2;HYEP;MGST3;U2AFM
Viral carcinogenesis ATF2;SCRIB;VDAC3;H2B2B;HA1D;LRRC1;CRLF1;VA0D1;CCND3;LRC58;H4;HDAC7;CDC20;EP300;CDK4;RANG;CCND1
MicroRNAs in cancer DIK2A;VIME;PGH2;IF2B1;ENSA;TSP1;HMOX1;EP300;CCND1
Transcriptional misregulation in cancer MLF1;PBX3;K319L;CEBPB;MITF;TNR16;Q9JLZ6
Proteoglycans in cancer SDC4;ESPN;TSP1;ITPR3;ITB5;FINC;ITAV;;CATL1;|CD63;CCND1
Choline metabolism in cancer DGKE;CTL2;CHKA
Central carbon metabolism in cancer GTR1
Cancers: Specific types Bladder cancer TSP1;CDK4;CCND1
Pancreatic cancer RALA;RALB;CDK4;CCND1
Renal cell carcinoma GTR1;EP300;RBX1
Colorectal cancer RALA;RALB;CCND1
Hepatocellular carcinoma GSTM6;GSTM7;MGST3;HMOX1;CDK4;CCND1
Endometrial cancer CCND1
Gastric cancer CCND1
  1. MS275 treatment versus Ctrl, p < 0.05
  2. Upright letters = upregulated; inclined letters = downregulated