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Table 4 Univariate and multivariate analysis of factors associated with advanced liver fibrosis

From: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis

Variables

Univariate analysis

Multivariate analysis

OR (95% CI)

P

OR (95% CI)

P

Age (years)

1.053 (1.010, 1.097)

0.016

  

Female

0.960 (0.312, 2.955)

0.943

  

Autoantibodies positive

2.674 (0.694, 10.302)

0.153

  

IgG (g/L)

1.084 (1.018, 1.154)

0.012

1.123 (1.023, 1.232)

0.014

ALT (U/L)

1.000 (0.999, 1.001)

0.820

  

AST (U/L)

1.001 (0.999, 1.002)

0.314

  

ALP (U/L)

1.006 (0.999, 1.014)

0.104

  

GGT (U/L)

1.002 (0.999, 1.004)

0.273

  

TBIL (μmol/L)

1.006 (1.001, 1.012)

0.029

  

ALB (g/L)

0.921 (0.851, 0.996)

0.039

  

PLT (× 109/L)

0.984 (0.976, 0.992)

 < 0.001

0.988 (0.979, 0.997)

0.013

PT (s)

1.876 (1.317, 2.673)

 < 0.001

1.758 (1.143, 2.704)

0.010

Iron (μmol/L)

1.023 (0.994, 1.054)

0.125

  

Transferrin (g/L)

0.494 (0.250, 0.977)

0.043

  

Ferritin (μg/L)

1.002 (1.001, 1.003)

0.002

1.002 (1.001, 1.004)

0.012

UIBC (μmol/L)

0.969 (0.947, 0.992)

0.008

  

TIBC (μmol/L)

0.943 (0.905, 0.984)

0.006

  

TSI (%)

1.023 (1.005, 1.041)

0.011

  
  1. OR odds ratio, CI confidence interval, IgG immunoglobulin G, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, GGT gamma-glutamyl transpeptidase, TBIL total bilirubin, ALB albumin, PLT platelet, PT prothrombin time, UIBC unsaturated iron binding capacity, TIBC total iron binding capacity, TSI transferrin saturation index