Study | Outcome | No of healthy controls | Reported LMR in healthy controls | Standard Deviation | No of untreated coeliac patients | Reported LMR in untreated coeliac | Standard Deviation | No of treated coeliac patients | Reported LMR in treated coeliac patients | Standard Deviation | Statistically calculated WMD (95% CI) | Statistically calculated SMD (95% CI) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Elia et al. 1991 | Control versus untreated coeliac | 24 | 0.021* | 0.020 | 15 | 0.152* | 0.120 | 0.131 (0.070, 0.192) | 1.736 (0.979, 2.492) | |||
Vogelsang et al. 2001 | Treated versus untreated coeliac | 16 | 0.12 | 0.058 | 19 | 0.028 | 0.028 | 0.092 (0.061, 0.123) | 2.085 (1.252, 2.919) | |||
Kuitunen et al. 1996 | Control versus untreated coeliac | 18 | 0.030 | 0.043 | 22 | 0.260 | 0.410 | 0.230 (0.058, 0.402) | 0.751 (0.106, 1.397) | |||
Kuitunen et al. 1996 | Control versus treated coeliac | 18 | 0.030 | 0.043 | 17 | 0.040 | 0.010 | 0.010 (-0.010, 0.030) | 0.316 (-0.351, 0.983) | |||
Kuitunen et al. 1996 | Treated versus untreated coeliac | 22 | 0.260 | 0.410 | 17 | 0.040 | 0.010 | 0.220 (0.049, 0.391) | 0.712 (0.059, 1.365) | |||
Ukabam et al. 1985 | Control versus untreated coeliac | 25 | 0.009 | 0.003 | 13 | 0.110 | 0.156 | 0.101 (0.016, 0.186) | 1.121 (0.402, 1.839) | |||
Ukabam et al. 1985 | Control versus treated coeliac | 25 | 0.009 | 0.003 | 13 | 0.016 | 0.016 | 0.007 (-0.002, 0.016) | 0.728 (0.037, 1.419) | |||
Ukabam et al. 1985 | Treated versus untreated coeliac | 13 | 0.110 | 0.156 | 13 | 0.016 | 0.016 | 0.094 (0.009, 0.179) | 0.848 (0.042, 1.653) | |||
Vilela et al. 2008 | Control versus treated coeliac | 15 | 0.003 | 0.003 | 22 | 0.013 | 0.016 | 0.010 (0.003, 0.017) | 0.785 (0.103, 1.466) | |||
Hamilton et al. 1987 | Control versus untreated coeliac | 33 | 0.036 | 0.021 | 4 | 0.296* | 1.308 | 0.264 (-1.018, 1.546) | 0.688 (-0.362, 1.739) | |||
Marsilio et al. 1998 | Control versus untreated coeliac | 30 | 0.024* | 0.006 | 10 | 0.072* | 0.025 | 0.048 (0.032, 0.064) | 3.623 (2.539, 4.708) | |||
Van Elburg et al. 1993 | Control versus untreated coeliac | 22 | 0.043* | 0.030 | 9 | 0.243* | 0.100 | 0.200 (0.133, 0.267) | 3.425 (2.251, 4.599) | |||
Rajani et al. 2016 | Control versus untreated coeliac | 26 | 0.022 | 0.016 | 65 | 0.043 | 0.070 | 0.021 (0.003, 0.039) | 0.351 (-0.106, 0.809) | |||
Rajani et al. 2016 | Control versus treated coeliac | 26 | 0.022 | 0.016 | 47 | 0.024 | 0.077 | 0.002 (-0.021, 0.025) | 0.032 (-0.447, 0.511) | |||
Rajani et al. 2016 | Treated versus untreated coeliac | 65 | 0.043 | 0.070 | 47 | 0.024 | 0.077 | 0.019 (0.009, 0.047) | 0.261 (0.155–0.638) | |||
Smecuol et al. 1997 | Treated versus untreated coeliac | 27 | 0.360* | 0.380 | 15 | 0.130* | 0.188 | 0.230 (0.058, 0.402) | 0.706 (0.056, 1.356) | |||
Smecuol et al. 2005 | Control versus untreated coeliac | 30 | 0.017* | 0.040 | 30 | 0.073* | 0.090 | 0.056 (0.021, 0.091) | 0.804 (0.277, 1.331) | |||
Juby et al. 1989 | Control versus untreated coeliac | 12 | 0.016* | 0.007 | 17 | 0.163* | 0.313 | 0.147 (-0.002, 0.296) | 0.610 (-0.147, 1.367) | |||
Novacek et al. 1999a | Untreated coeliac disease with normal liver function tests | 106 | 0.110 | 0.315 | ||||||||
Novacek et al. 1999b | Untreated coeliac disease with abnormal liver function tests before versus after gluten free diet | 72 | 0.340 | 1.400 | 64 | 0.050 | 0.070 | 0.290 (0.034, 0.614) | 0.284 (0.054, 0.623) | |||
Vecsei et al. 2009 | Treated versus untreated coeliac | 47 | 0.177 | 47 | 0.053 | |||||||
Johnston et al. 2000 | Control versus untreated coeliac | 21 | 0.013* | 16 | 0.105* | |||||||
Johnston et al. 2000 | Control versus treated coeliac | 21 | 0.013* | 7 | 0.013* | |||||||
Johnston et al. 2000 | Treated versus untreated coeliac | 16 | 0.105* | 7 | 0.013* | |||||||
Catassi et al. 1997 | Control versus untreated coeliac | 54 | 0.014 | 29 | 0.038 | |||||||
Smecuol et al. 1999 | Untreated coeliac disease | 12 | 0.101 | 0.069 | ||||||||
Smecuol et al. 2013a | Untreated coeliac disease | 10 | 0.110 | 0.159 | ||||||||
Smecuol et al. 2013b | Untreated coeliac disease | 12 | 0.054 | 0.440 | ||||||||
Gatti et al. 2013a | Treated coeliac disease | 75 | 0.055 | 0.04 | ||||||||
Gatti et al. 2013b | Treated coeliac disease | 96 | 0.052 | 0.055 |