Table 4 Univariate and multivariate analyses on predictors of long-term fistula healing in early infliximab induction group (n = 73)
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | p value | HR (95%CI) | p value | |
Sex (male) | 0.456 (0.152–1.373) | 0.163 | ||
Age at inclusion | 1.042 (0.977–1.111) | 0.213 | ||
Complex fistula | 1.625 (0.293–9.007) | 0.578 | ||
Proctitis | 1.2 (0.452–3.186) | 0.714 | ||
Anorectal stricture | 2.462 (0.922–6.572) | 0.072 | ||
Presence of abscess at baseline | 3.429 (1.216–9.668) | 0.02 | 3.429 (1.216–9.668) | 0.02 |
Previous perianal surgery | 0.8 (0.311–2.06) | 0.644 | ||
Disease behavior | ||||
B1-inflammation | ||||
B2/B3-stricturing/penetrating | 2.133 (0.798–5.704) | 0.131 | ||
Disease location | 0.752 | |||
L1-ileal | ||||
L2-colonic | 1.111 (0.22–5.616) | 0.899 | ||
L3-ileocolonic | 0.897 (0.27–2.988) | 0.86 | ||
L4-upper gastrointestinal | 2.222 (0.365–13.538) | 0.386 | ||
Maintenance with infliximab | ||||
≤ 3 infusions | ||||
> 3 infusions | 1.319 (0.512–3.396) | 0.566 | ||
Need re-intervention | 2.383 (0.882–6.440) | 0.087 | ||