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Table 4 Univariate and multivariate analyses on predictors of long-term fistula healing in early infliximab induction group (n = 73)

From: Combined therapy with early initiation of infliximab following drainage of perianal fistulising Crohn’s disease: a retrospective cohort study

Variable Univariate analysis Multivariate analysis
HR (95%CI) p value HR (95%CI) p value
Sex (male) 0.456 (0.152–1.373) 0.163   
Age at inclusion 1.042 (0.977–1.111) 0.213   
Complex fistula 1.625 (0.293–9.007) 0.578   
Proctitis 1.2 (0.452–3.186) 0.714   
Anorectal stricture 2.462 (0.922–6.572) 0.072   
Presence of abscess at baseline 3.429 (1.216–9.668) 0.02 3.429 (1.216–9.668) 0.02
Previous perianal surgery 0.8 (0.311–2.06) 0.644   
Disease behavior     
 B1-inflammation     
 B2/B3-stricturing/penetrating 2.133 (0.798–5.704) 0.131   
Disease location   0.752   
 L1-ileal     
 L2-colonic 1.111 (0.22–5.616) 0.899   
 L3-ileocolonic 0.897 (0.27–2.988) 0.86   
 L4-upper gastrointestinal 2.222 (0.365–13.538) 0.386   
Maintenance with infliximab     
 ≤ 3 infusions     
 > 3 infusions 1.319 (0.512–3.396) 0.566   
Need re-intervention 2.383 (0.882–6.440) 0.087   
  1. HR hazard ratio, CI confidence interval