Table 3 Univariate and multivariate analyses on predictors of surgical re-intervention in early infliximab induction group (n = 73)
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | p value | HR (95%CI) | p value | |
Sex (male) | 0.941 (0.302–2.938) | 0.917 | ||
Age at inclusion | 0.983 (0.92–1.05) | 0.614 | ||
Complex fistula | 3.429 (0.389–30.197) | 0.267 | ||
Proctitis | 0.698 (0.260–1.872) | 0.475 | ||
Anorectal stricture | 0.938 (0.343–2.559) | 0.9 | ||
Presence of abscess at baseline | 4.727 (1.523–14.672) | 0.007 | 5.283 (1.61–17.335) | 0.006 |
Previous perianal surgery | 0.917 (0.348–2.414) | 0.86 | ||
Disease behavior | ||||
B1-inflammation | ||||
B2/B3-stricturing/penetrating | 0.594 (0.208–1.692) | 0.329 | ||
Disease location | 0.329 | |||
L1-ileal | ||||
L2-colonic | 2.2 (0.431–11.219) | 0.343 | ||
L3-ileocolonic | 0.834 (0.236–2.955) | 0.779 | ||
L4-upper gastrointestinal | 2.933 (0.469–18.333) | 0.25 | ||
Maintenance with infliximab | ||||
≤ 3 infusions | ||||
> 3 infusions | 3.243 (1.169–8.996) | 0.024 | 3.691 (1.233–11.051) | 0.020 |