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Table 3 Univariate and multivariate analyses on predictors of surgical re-intervention in early infliximab induction group (n = 73)

From: Combined therapy with early initiation of infliximab following drainage of perianal fistulising Crohn’s disease: a retrospective cohort study

Variable Univariate analysis Multivariate analysis
HR (95%CI) p value HR (95%CI) p value
Sex (male) 0.941 (0.302–2.938) 0.917   
Age at inclusion 0.983 (0.92–1.05) 0.614   
Complex fistula 3.429 (0.389–30.197) 0.267   
Proctitis 0.698 (0.260–1.872) 0.475   
Anorectal stricture 0.938 (0.343–2.559) 0.9   
Presence of abscess at baseline 4.727 (1.523–14.672) 0.007 5.283 (1.61–17.335) 0.006
Previous perianal surgery 0.917 (0.348–2.414) 0.86   
Disease behavior     
 B1-inflammation     
 B2/B3-stricturing/penetrating 0.594 (0.208–1.692) 0.329   
Disease location   0.329   
 L1-ileal     
 L2-colonic 2.2 (0.431–11.219) 0.343   
 L3-ileocolonic 0.834 (0.236–2.955) 0.779   
 L4-upper gastrointestinal 2.933 (0.469–18.333) 0.25   
Maintenance with infliximab     
 ≤ 3 infusions     
 > 3 infusions 3.243 (1.169–8.996) 0.024 3.691 (1.233–11.051) 0.020
  1. HR hazard ratio, CI confidence interval