Table 3 Univariate associations of clinicopathological characteristics and PSPH expression with OS in the 234 gastric patients
Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age | ||||
 ≤ 59 | 1 (reference) |  |  |  |
 > 59 | 1.23 (0.82–1.85) | 0.313 |  |  |
Gender | ||||
 Male | 1 (reference) |  |  |  |
 Female | 1.01 (0.66–1.54) | 0.986 |  |  |
Lauren classification | ||||
 Intestinal-type | 1 (reference) |  | 1 (reference) |  |
 Diffuse-type | 1.81 (1.04–3.15) | 0.037 | 1.32 (0.73–2.39) | 0.346 |
 Mixed | 2.24 (1.23–4.08) | 0.008 | 1.23 (0.66–2.29) | 0.507 |
Invasion depth | ||||
 T1 | 1 (reference) |  | 1 (reference) |  |
 T2 | 2.33 (0.43–12.73) | 0.328 | 4.08 (0.44–37.11) | 0.212 |
 T3 | 3.51 (0.83–14.9) | 0.088 | 3.62 (0.45–28.67) | 0.222 |
 T4 | 14.94 (3.65–61.17) |  < 0.001 | 10.55 (1.32–84.30) | 0.026 |
Lymph node metastasis | ||||
 Negative | 1 (reference) |  | 1 (reference) |  |
 Positive | 3.79 (1.96–7.32) |  < 0.001 | 1.08 (0.39–2.96) | 0.868 |
Distant metastasis | ||||
 Negative | 1 (reference) |  | 1 (reference) |  |
 Positive | 5.74 (3.56–9.25) | < 0.001 | 2.61 (1.55–4.39) | < 0.001 |
Stage | ||||
 I + II | 1 (reference) |  | 1 (reference) |  |
 III + IV | 5.51 (3.06–9.93) | < 0.001 | 2.10 (0.76–5.77) | 0.150 |
PSPH expression | ||||
 Low | 1 (reference) |  | 1 (reference) |  |
 High | 1.53 (1.01–2.34) | 0.041 | 1.30 (0.81–2.08) | 0.275 |